Astragaloside IV Ameliorates Airway Inflammation in an Established Murine Model of Asthma by Inhibiting the mTORC1 Signaling Pathway

Figure 4

The effect of AS-IV on airway inflammation in the lung tissue. Histopathological analysis: removed lung tissue slices were fixed, embedded, sectioned at 3-4 μm, and stained with hematoxylin and eosin; they were then observed under a microscope (100x). The inflammation score represents the severity of inflammatory cell infiltration in the airway. Representative photomicrographs from each group ( per group) were shown as follows: (a) saline; (b) OVA reexposure; (c) dexamethasone (Dex) (1 mg/kg/day); (d) rapamycin (Rapa) (4 mg/kg/day); (e) AS-IV 10 mg/kg group; (f) AS-IV 20 mg/kg; and (g) AS-IV 40.0 mg/kg group. The data were expressed as the mean ± SEM. versus the OVA reexposure group.