¹H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Figure 2

(a) PLS-DA score plot of model group (MS) and normal control group (NS) after 7-day model establishment, showing the degree of separation of the model between MS (black squares) and NS (red dots) ( = 51.1%, = 74.9%, = 51.7%); (b) a 200-iteration permutation test in the above PLS-DA model showing (green triangles) and (blue squares) values from permuted analysis (bottom left) significantly lower than the corresponding unpermuted values (top right); (c) PCA score plot of MS, NS, and Weikangning-treated group (WKN) after 14-day drug treatment, performing discrimination between MS (black squares), NS (red dots), and WKN (blue diamonds) ( = 51.4%, = 26.5%); (d) PLS-DA score plot of MS, NS, and WKN on postdose day 14, showing the degree of separation of the MS (black squares), NS (red dots), and WKN (blue diamonds) ( = 23.8%, = 81.0%, and = 38.7%); (e) score plot of the metabolic changing process from PLS-DA model in MS, showing the changing process from predose day −1 (black squares), predose day 7 (red dots), postdose day 7 (shown as day 14, blue diamonds), and postdose day 14 (shown as day 21, green stars)  ( = 25.6%, = 48.2%, and = 23.3%); (f) score plot of the metabolic changing process from PLS-DA model in WKN, showing the changing process from predose day −1 (black squares), predose day 7 (red dots), postdose day 7 (shown as day 14, blue diamonds), and postdose day 14 (shown as day 21, green stars) ( = 21.5%, = 55.9%, and = 29.7%).

(a)

(b)

(c)

(d)

(e)

(f)