¹H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Figure 6

(a) PCA score plot of model group (MS), normal control group (NS), and Weikangning-treated group (WKN) after 14-day drug treatment, performing discrimination between MS (black squares), NS (red dots), and WKN (blue diamonds) ( = 59.1%, = 11.5%); (b) PLS-DA score plot of MS, NS, and WKN on postdose day 14, showing the degree of separation of the MS (black squares), NS (red dots), and WKN groups (blue diamonds) ( = 15.1%, = 78.0%, and = 5.5%); (c) OPLS-DA score plot of model group (MS) and normal control group (NS) on postdose day 14, displaying the degree of separation between the MS (black squares) and NS (red dots) ( = 17.7%, = 99.2%, and = 28.9%); (d) OPLS-DA corresponding color-coded correlation coefficient loading plot of key metabolites based on the metabolic information from MS and NS groups on postdose day 14, demonstrating discrimination of key metabolite levels between the two groups; (e) OPLS-DA score plot of MS and WKN-treated (WKN) groups on postdose day 14, showing the degree of separation between the MS (black squares) and WKN groups (blue diamonds) ( = 20.1%, = 97.6%, and = 37.2%); (f) OPLS-DA corresponding color-coded correlation coefficient loading plot of key metabolites based on the metabolic information from MS and WKN groups on postdose day 11, showing differences in the levels of key metabolites between the two groups.

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