Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 2

Research Article

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 2

Quantitative comparison of metabolites identified in urine of Weikangning-treated group (WKN) and model group (MS).

MetabolitesChemical shiftIntegral in WKN group (mean ± S.D.) × 10−2Integral in MS group (mean ± S.D.) × 10−2
VIP
(P < 0.05)

2-Hydroxyvalerate0.91 (t)4.087 ± 1.1805.443 ± 1.093 (↓)1.7620.041
Leucine0.95 (dd)5.711 ± 0.8578.219 ± 1.782 (↓)1.8840.001
Alanine1.48 (d)3.558 ± 0.3454.877 ± 0.981 (↓)1.7440.003
Adipate1.555 (m)5.492 ± 0.6536.826 ± 1.032−0.645 (↓)1.8160.003
N-Acetylglutamate2.22 (t)22.047 ± 7.3607.318 ± 0.9130.826 (↑)2.2670.000
Glucose3.525 (dd), 3.82 (ddd, m)21.412 ± 2.62515.989 ± 1.0420.930 (↑)2.3970.000
Glycine3.57 (s)9.757 ± 0.99412.134 ± 2.001 (↓)1.6250.005
Creatine3.925 (t)13.164 ± 1.17311.213 ± 1.0260.801 (↑)1.8780.001
Hippurate3.965 (d), 7.555 (t), 7.63 (t), 7.83 (t)21.440 ± 4.30715.534 ± 2.0230.708 (↑)2.0270.002
Trigonelline4.435 (s)4.575 ± 1.2323.358 ± 0.7850.657 (↑)1.6350.017
cis-Aconitate5.69 (s)2.330 ± 0.9324.625 ± 2.431 (↓)1.4980.017
Phenylalanine7.42 (t)4.416 ± 1.5836.770 ± 2.040 (↓)1.8560.010
Formate8.46 (s)0.970 ± 0.2920.387 ± 0.1020.803 (↑)2.2890.000

The relative integrals of metabolites were determined by 1D 1H NMR analysis of urine. The values of the correlation number extracted from the correlation plots of OPLS-DA models of WKN versus MS groups. The P values were obtained from Independent-Samples t-test or -test (shown with ). The P values were calculated by Mann–Whitney U test of nonparametric tests and the related integrals were presented in median ± IQR. The arrows (↑/↓) denote higher/lower amounts relative to MS group.

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