¹H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 3

Quantitative comparison of metabolites identified in serum of model group (MS) and normal control group (NS).

Metabolites	Chemical shift	Integral in MS group (mean ± S.D.) × 10^−2	Integral in NS group (mean ± S.D.) × 10^−2	( > 0.632)	VIP	(P < 0.05)
Isoleucine	0.94 (t)	0.146 ± 0.037	0.116 ± 0.020	0.702 (↑)	2.350	0.035
Leucine	0.96 (dd)	0.220 ± 0.043	0.193 ± 0.019	0.693 (↑)	2.368	0.010
Proline	2.07 (m)	0.085 ± 0.014	0.067 ± 0.006	0.661 (↑)	2.227	0.002
Methanol	3.36 (s)	0.385 ± 0.165	0.195 ± 0.032	0.769 (↑)	2.674	0.005
Glucose	3.705 (t)	0.314 ± 0.114	0.425 ± 0.090	−0.642 (↓)	2.237	0.026

The relative integrals of metabolites were determined by 1D ¹H NMR analysis of urine. The values of the correlation number extracted from the correlation plots of OPLS-DA models of MS versus NS groups. The P values were obtained from Independent-Samples t-test or -test (shown with ). The P values were calculated by Mann–Whitney U test of nonparametric tests and the related integrals were presented in median ± IQR. The arrows (↑/↓) denote higher/lower amounts relative to NS group.