Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 4

Research Article

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 4

Quantitative comparison of metabolites identified in serum of Weikangning-treated group (WKN) and model group (MS).

MetabolitesChemical shiftIntegral in WKN group (mean ± S.D.) × 10−2Integral in MS group (mean ± S.D.) × 10−2
VIP
(P < 0.05)

Proline2.04 (m)0.300 ± 0.0400.357 ± 0.0690.660 (↓)2.5350.023
Glutamate2.105 (m)0.040 ± 0.0050.052 ± 0.0110.656 (↓)2.1750.001
3-Hydroxybutyrate2.355 (m)0.080 ± 0.0130.112 ± 0.0280.730 (↓)2.3200.008
Citrate2.555 (AB)0.008 ± 0.0020.012 ± 0.0020.707 (↓)2.2820.001
Methionine2.645 (t)0.034 ± 0.0060.042 ± 0.0100.739 (↓)2.4300.045
Glucose3.44 (t), 3.5 (t), 3.725 (dd), 3.9 (dd)0.120 ± 0.0130.096 ± 0.022−0.736 (↑)2.4300.010
Glycerol3.67 (ABX)0.134 ± 0.0140.165 ± 0.0470.697 (↓)2.1600.041
1-Methylhistidine7.04 (s)0.000 ± 0.0010.003 ± 0.0020.639 (↓)2.2420.007
Phenylalanine7.32 (m), 7.375 (m)0.000 ± 0.0020.004 ± 0.0070.668 (↓)2.3740.002
Formate8.46 (s)0.038 ± 0.0060.058 ± 0.0230.714 (↓)2.5910.001

The relative integrals of metabolites were determined by 1D 1H NMR analysis of urine. The values of the correlation number extracted from the correlation plots of OPLS-DA models of WKN versus MS groups. The P values were obtained from Independent-Samples t-test or -test (shown with ). The P values were calculated by Mann–Whitney U test of nonparametric tests and the related integrals were presented in median ± IQR. The arrows (↑/↓) denote higher/lower amounts relative to MS group.

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