¹H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 4

Quantitative comparison of metabolites identified in serum of Weikangning-treated group (WKN) and model group (MS).


Metabolites	Chemical shift	Integral in WKN group (mean ± S.D.) × 10⁻²	Integral in MS group (mean ± S.D.) × 10⁻²		VIP	(P < 0.05)

Proline	2.04 (m)	0.300 ± 0.040	0.357 ± 0.069	0.660 (↓)	2.535	0.023
Glutamate	2.105 (m)	0.040 ± 0.005	0.052 ± 0.011	0.656 (↓)	2.175	0.001
3-Hydroxybutyrate	2.355 (m)	0.080 ± 0.013	0.112 ± 0.028	0.730 (↓)	2.320	0.008
Citrate	2.555 (AB)	0.008 ± 0.002	0.012 ± 0.002	0.707 (↓)	2.282	0.001
Methionine	2.645 (t)	0.034 ± 0.006	0.042 ± 0.010	0.739 (↓)	2.430	0.045
Glucose	3.44 (t), 3.5 (t), 3.725 (dd), 3.9 (dd)	0.120 ± 0.013	0.096 ± 0.022	−0.736 (↑)	2.430	0.010
Glycerol	3.67 (ABX)	0.134 ± 0.014	0.165 ± 0.047	0.697 (↓)	2.160	0.041
1-Methylhistidine	7.04 (s)	0.000 ± 0.001	0.003 ± 0.002	0.639 (↓)	2.242	0.007
Phenylalanine	7.32 (m), 7.375 (m)	0.000 ± 0.002	0.004 ± 0.007	0.668 (↓)	2.374	0.002
Formate	8.46 (s)	0.038 ± 0.006	0.058 ± 0.023	0.714 (↓)	2.591	0.001

The relative integrals of metabolites were determined by 1D ¹H NMR analysis of urine. The values of the correlation number extracted from the correlation plots of OPLS-DA models of WKN versus MS groups. The P values were obtained from Independent-Samples t-test or -test (shown with ). The P values were calculated by Mann–Whitney U test of nonparametric tests and the related integrals were presented in median ± IQR. The arrows (↑/↓) denote higher/lower amounts relative to MS group.

Evidence-Based Complementary and Alternative Medicine

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Table 4

¹H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning