Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice

Table 4

In vivo antidiarrheal indices of 80% MeOH-E and solvent fractions of M. kummel fruits.

Extracts	Dose administered	Delay in defecation (time of onset in min, Dfreq) (%)	Gut meal travel distance (Gmeq) (%)	Purging frequency in number of wet stools (Pfreq) (%)	Antidiarrheal; index (ADI)
80% MeOHE	100 mg/kg	51.14	57.66	71.40	59.49
	200 mg/kg	110.53	63.14	76.70	81.19
	400 mg/kg	149.65	68.98	85.70	96.00
	3 mg/kg loperamide	180.10	66.06	79.40	98.12
Solvent fractions	CF100 mg/kg	35.41	11.83	9.76	15.99
	CF200 mg/kg	62.69	24.73	31.41	36.52
	CF400 mg/kg	90.28	32.05	39.18	48.40
Solvent fractions	n-BF100 mg/kg	66.13	19.15	19.65	29.20
	n-BF200 mg/kg	92.16	31.06	45.06	50.53
	n-BF400 mg/kg	131.65	42.20	56.82	68.09
Solvent fractions	AF100 mg/kg	74.29	36.92	60.82	55.05
	AF200 mg/kg	114.09	49.47	68.59	72.88
	AF400 mg/kg	130.07	56.45	70.59	80.33
Solvent fractions	3 mg/kg loperamide	153.58	63.77	80.35	92.32

80% MeOH-E = 80% methanolic extract, CF = chloroform fraction, n-BF = n-butanol fraction, and AF = aqueous fraction.