Efficacy and Safety of an Herbal Therapy in Patients with Amnestic Mild Cognitive Impairment: A 24-Week Randomized Phase III Trial

Table 2

Changes from baseline to the end of the study on efficacy measures after 24 weeks of treatment in patients with aMCI (ITT-LOCF analyses).

Change from baseline to endpoint	Herbal therapy		Donepezil		value
	Mean (SD)	95% CI	Mean (SD)	95% CI
	ADAS-cog	−4.23 (3.57)	−4.71~−3.75	−4.31 (3.61)		−4.99~−3.63	0.000
DSR	+9.45 (7.08)	+8.50~10.40	+9.9 (7.53)	+8.49~11.34	0.000

Data are mean (SD) changes in score from baseline to 24 weeks. value for the comparison between the donepezil group and herbal group of the mean change from baseline. ADAS-cog = Alzheimer’s Disease Assessment Scale-cognitive subscale; DSR = Delayed Story Recall.