Fraxinus: A Plant with Versatile Pharmacological and Biological Activities

Table 2

Molecular targets of Fraxinus plant in various cancer types.

Type of cancer	Cell lines	EC50/conc.	Molecular targets	References
Breast	MCF-7	18.95 µg/ml, 35.622 µg/ml	NO↑	[54, 55]
Leukemia	K562, RPMI-8226, L1210	20 μg/ml	PKB phosphorylation⊥, Mcl-1↓, ERK-1/2⊥	[56]
Gastric	AGS	37.338 μg/ml		[55]
Colon	SW742, HCT-8	31.092 μg/ml, 3.4 μM		[46, 55]
Lung	SKLC6, A549	68.072 μg/ml, 6.0 µM		[55, 57]
Skin	A375	51.849 μg/ml		[55]
Ovary	A2780	1.7 µM		[57]
Liver	PLC/PRF/5	21.036 μg/ml		[55]