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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 4317321, 10 pages
https://doi.org/10.1155/2017/4317321
Research Article

Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone-Induced Obese Mice

1Department of Chemistry and Biochemistry, School of Science, University of Eldoret, Eldoret, Kenya
2Department of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya

Correspondence should be addressed to Kathryn Wanjiku Nderitu; moc.liamg@672utirednk

Received 8 May 2017; Revised 24 July 2017; Accepted 1 August 2017; Published 30 August 2017

Academic Editor: Srinivas Nammi

Copyright © 2017 Kathryn Wanjiku Nderitu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, “Obesity: preventing and managing the global epidemic (No. 894),” 2000.
  2. J. B. Dixon, “The effect of obesity on health outcomes,” Molecular and Cellular Endocrinology, vol. 316, no. 2, pp. 104–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Poirier, T. D. Giles, G. A. Bray et al., “Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 5, pp. 968–976, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. S. Derdemezis, T. D. Filippatos, D. P. Mikhailidis, and M. S. Elisaf, “Effects of plant sterols and stanols beyond low-density lipoprotein cholesterol lowering,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 15, no. 2, pp. 120–134, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. B. M. Popkin, L. S. Adair, and S. W. Ng, “Global nutrition transition and the pandemic of obesity in developing countries,” Nutrition Reviews, vol. 70, no. 1, pp. 3–21, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. S. M. Grundy, “Obesity, metabolic syndrome, and cardiovascular disease,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2595–2600, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. M. Ordovas and J. Shen, “Gene-environment interactions and susceptibility to metabolic syndrome and other chronic diseases,” Journal of Periodontology, vol. 79, no. 8, pp. 1508–1513, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. J. Wallis and M. M. Hetherington, “Emotions and eating. Self-reported and experimentally induced changes in food intake under stress,” Appetite, vol. 52, no. 2, pp. 355–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. D. W. Dunstan, J. Salmon, N. Owen et al., “Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults,” Diabetologia, vol. 48, no. 11, pp. 2254–2261, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. M. T. Hamilton, D. G. Hamilton, and T. W. Zderic, “Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease,” Diabetes, vol. 56, no. 11, pp. 2655–2667, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Shrestha, B. R. Bhattarai, K.-H. Lee, and H. Cho, “Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs,” Bioorganic and Medicinal Chemistry, vol. 15, no. 20, pp. 6535–6548, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Kishino, T. Ito, K. Fujita, and Y. andKiuchi, “A mixture of the Salaciareticulata (Kotalahimbutu) aqueous extract and cyclodextrin reduces the accumulation of visceral fat mass in mice and rats with high-fat dietinduced obesity,” Journal of Nutrition, vol. 136, no. 2, pp. 433–439, 2006. View at Google Scholar
  13. P. Bagri, M. Ali, V. Aeri, M. Bhowmik, and S. Sultana, “Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes,” Food and Chemical Toxicology, vol. 47, no. 1, pp. 50–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Lee, K. Chae, J. Ha et al., “Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice,” Journal of Ethnopharmacology, vol. 115, no. 2, pp. 263–270, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. A. Grove and J. D. Lambert, “Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity,” Journal of Nutrition, vol. 140, no. 3, pp. 446–453, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Haaz, K. R. Fontaine, G. Cutter, N. Limdi, S. Perumean-Chaney, and D. B. Allison, “Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update,” Obesity Reviews, vol. 7, no. 1, pp. 79–88, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. L.-K. Han, M. Sumiyoshi, J. Zhang et al., “Anti-obesity action of Salix matsudana leaves (part 1). Anti-obesity action by polyphenols of salix matsudana in high fat-diet treated rodent animals,” Phytotherapy Research, vol. 17, no. 10, pp. 1188–1194, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. F. J. Alarcon-Aguilar, A. Zamilpa, M. D. Perez-Garcia et al., “Effect of Hibiscus sabdariffa on obesity in MSG mice,” Journal of Ethnopharmacology, vol. 114, no. 1, pp. 66–71, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi, “Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats,” Journal of Ethnopharmacology, vol. 106, no. 2, pp. 238–244, 2006. View at Publisher · View at Google Scholar
  20. P. Weththasinghe, R. Liyanage, J. Vidanarachchi, O. Perera, and B. Jayawardana, “Hypocholesterolemic and hypoglycemic effect of cowpea (Vigna unguiculata L. Walp) incorporated experimental diets in wistar rats (Rattus norvegicus),” Agricultural Science Procedia, vol. 2, pp. 401–405, 2014. View at Publisher · View at Google Scholar
  21. A. Sedigheh, M. S. Jamal, S. Mahbubeh et al., “Hypoglycaemic and hypolipidemic effects of pumpkin (cucurbita pepo l.) on alloxan-induced diabetic rats,” African Journal of Pharmacy and Pharmacology, vol. 5, no. 23, pp. 2620–2626, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Unakal and M. Newman, “Antidiabetic activity of Amaranthus dubiousethanolic leaf extract on alloxan induced diabetic mice,” International Journal of Current Microbiology and Applied Sciences, vol. 3, no. 2, pp. 584–590, 2014. View at Google Scholar
  23. G. A. Y. Koua, L. T. Zoue, S. Ouattara, and S. L. Niamke, “Studies on nutritive value and antioxidant properties of three neglected leafy vegetables of Cote d’Ivoire,” Pakistan Journal of Nutrition, vol. 14, no. 12, pp. 877–884, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. A. P. Rauter, A. Martins, C. Borges et al., “Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats,” Phytotherapy Research, vol. 24, supplement 2, pp. S133–S138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Gundamaraju, D. V. Atigari, and D. S. andSheeba, “Evaluation of anti-obesity activity of Lantana camaravar Linn on butter induced Hyperlipidemia in rats,” Journal of Pharmacology and Pharmacodynamics, vol. 4, no. 5, pp. 315–318, 2012. View at Google Scholar
  26. M. O. Lee, “Determination of the surface area of the white rat with its application to the expression of metabolic results,” Journal of Physiology—Legacy Content, vol. 89, no. 1, pp. 24–33, 1929. View at Google Scholar
  27. V. R. Chidrawar, K. N. Patel, S. S. Shiromwar, and A. D. Kshirsagar, “Exploiting anti-obesity mechanism of Clerodendrum phlomidis against two different models of rodents,” International Journal of Green Pharmacy, vol. 5, no. 3, pp. 216–228, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. A. J. Harborne, “Phytochemical methods a guide to modern techniques of plant analysis,” Springer Science and Business Media, vol. 3, no. 1, pp. 87–91, 1998. View at Publisher · View at Google Scholar
  29. A. B. de Gonzalez, P. Hartge, J. R. Cerhan et al., “Body-mass index and mortality among 1.46 million white adults,” New England Journal of Medicine, vol. 363, no. 23, pp. 2211–2219, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Tziomalos, G. E. Krassas, and T. Tzotzas, “The use of sibutramine in the management of obesity and related disorders: an update,” Vascular Health and Risk Management, vol. 5, pp. 441–452, 2009. View at Google Scholar · View at Scopus
  31. A. Safia and K. Krishna, “Evaluation of hypolipidemic and anti-obesity activities of Momordica dioica Roxb. fruit extracts on atherogenic diet induced hyperlipidemic rats,” Pharmacophore, vol. 4, no. 6, pp. 215–221, 2013. View at Google Scholar
  32. B. D. Kretschmer, P. Schelling, N. Beier et al., “Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance,” Life Sciences, vol. 76, no. 14, pp. 1553–1573, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. S. R. Galaly, W. G. Hozayen, K. A. Amin, and S. M. Ramadan, “Effects of Orlistat and herbal mixture extract on brain, testes functions and oxidative stress biomarkers in a rat model of high fat diet,” Beni-Suef University Journal of Basic and Applied Sciences, vol. 3, no. 2, pp. 93–105, 2014. View at Publisher · View at Google Scholar
  34. Y. Ozkan, S. Aydin, E. Donder et al., “Effect of orlistat on the total ghrelin and leptin levels in obese patients,” Journal of Physiology and Biochemistry, vol. 65, no. 3, pp. 215–223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Kaur and S. K. Kulkarni, “Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice,” Brain Research, vol. 943, no. 2, pp. 206–215, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. A. B. Berenson and M. Rahman, “Changes in weight, total fat, percent body fat, and central-to-peripheral fat ratio associated with injectable and oral contraceptive use,” American Journal of Obstetrics and Gynecology, vol. 200, no. 3, pp. 329–338, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. K. R. Abinaya and R. Pavitra, “Management of obesity and its related disease by herbal drugs,” International Journal of Ayurvedic and Herbal Medicine, vol. 4, no. 3, pp. 1470–1479, 2014. View at Google Scholar
  38. E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima, “Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice,” Planta Medica, vol. 73, no. 12, pp. 1255–1259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. P. Majumdar, S. Banerjee, J. Nautiyal et al., “Curcumin synergizes with resveratrol to inhibit colon cancer,” Nutrition and Cancer, vol. 61, no. 4, pp. 544–553, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Bais, G. S. Singh, and R. Sharma, “Antiobesity and hypolipidemic activity of Moringaoleifera leaves against high fat diet-induced obesity in rats,” Advances in Biology, vol. 2014, Article ID 162914, 9 pages, 2014. View at Publisher · View at Google Scholar
  41. P. Dzomba and C. Musekiwa, “Anti-obesity and antioxidant activity of dietary flavonoids from Dioscorea steriscus tubers,” Journal of Coastal Life Medicine, vol. 2, pp. 465–470, 2014. View at Publisher · View at Google Scholar
  42. J. S. Choi, J.-H. Kim, M. Y. Ali, B.-S. Min, G.-D. Kim, and H. A. Jung, “Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ,” Fitoterapia, vol. 98, pp. 199–208, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. P. W. Sullivan, V. H. Ghushchyan, and R. Ben-Joseph, “The impact of obesity on diabetes, hyperlipidemia and hypertension in the United States,” Quality of Life Research, vol. 17, no. 8, pp. 1063–1071, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. C. J. Lavie, R. V. Milani, and H. O. Ventura, “Obesity and cardiovascular disease risk factor, paradox, and impact of weight loss,” Journal of the American College of Cardiology, vol. 53, no. 21, pp. 1925–1932, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. I. J. Goldberg, R. H. Eckel, and R. McPherson, “Triglycerides and heart disease: still a hypothesis?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 8, pp. 1716–1725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. K. Chung, “Vitamins, supplements, herbal medicines, and arrhythmias,” Cardiology in Review, vol. 12, no. 2, pp. 73–84, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. F. H. O'Neill, T. A. B. Sanders, and G. R. Thompson, “Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies,” American Journal of Cardiology, vol. 96, no. 1, pp. 29–36, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. M. C. Izar, D. M. Tegani, S. H. Kasmas, and F. A. Fonseca, “Phytosterols and phytosterolemia: gene-diet interactions,” Genes and Nutrition, vol. 6, no. 1, pp. 17–26, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. M. B. Katan, S. M. Grundy, P. Jones, M. Law, T. Miettinen, and R. Paoletti, “Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels,” Mayo Clinic Proceedings, vol. 78, no. 8, pp. 965–978, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Uemura, T. Goto, M.-S. Kang et al., “Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice,” Journal of Nutrition, vol. 141, no. 1, pp. 17–23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. T. Wang, R. C. Y. Choi, J. Li et al., “Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of dioscorea nipponica,” Planta Medica, vol. 76, no. 15, pp. 1642–1646, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. H. Kang, Y.-S. Lee, K. K. Kim, D. J. Kim, T. W. Kim, and M. Choe, “Study on antioxidative, antidiabetic and antiobesity activity of solvent fractions of smilax china L. leaf extract,” Journal of Nutrition and Health, vol. 46, no. 5, pp. 401–409, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. S. Patra, S. Nithya, B. Srinithya, and S. M. Meenakshi, “Review of medicinal plants for anti-obesity activity,” Translational Biomedicine, vol. 6, no. 3, 2015. View at Publisher · View at Google Scholar
  54. M. Hamao, H. Matsuda, S. Nakamura et al., “Anti-obesity effects of the methanolic extract and chakasaponins from the flower buds of Camellia sinensis in mice,” Bioorganic and Medicinal Chemistry, vol. 19, no. 20, pp. 6033–6041, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. A. L. de la Garza, F. I. Milagro, N. Boque, J. Campión, and J. A. Martínez, “Natural inhibitors of pancreatic lipase as new players in obesity treatment,” Planta Medica, vol. 77, no. 8, pp. 773–785, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. J.-H. Kang, G. Tsuyoshi, I.-S. Han, T. Kawada, Y. M. Kim, and R. Yu, “Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet,” Obesity, vol. 18, no. 4, pp. 780–787, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. J. Oben, D. Kuate, G. Agbor, C. Momo, and X. Talla, “The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome,” Lipids in Health and Disease, vol. 5, no. 1, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. J. H. Kim, D. H. Hahm, D. C. Yang, J. H. Kim, H. J. Lee, and I. Shim, “Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat,” Journal of Pharmacological Sciences, vol. 97, no. 1, pp. 124–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  59. L. Iughetti, R. Berri, M. China, and B. Predieri, “Current and future drugs for appetite regulation and obesity treatment,” Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, vol. 3, no. 2, pp. 102–128, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. J.-R. Jeon and J.-Y. Kim, “Effects of pine needle extract on differentiation of 3T3-L1 preadipocytes and obesity in high-fat diet fed rats,” Biological and Pharmaceutical Bulletin, vol. 29, no. 10, pp. 2111–2115, 2006. View at Publisher · View at Google Scholar · View at Scopus