Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 4389048, 10 pages
https://doi.org/10.1155/2017/4389048
Research Article

Dai-Huang-Fu-Zi-Tang Alleviates Intestinal Injury Associated with Severe Acute Pancreatitis by Regulating Mitochondrial Permeability Transition Pore of Intestinal Mucosa Epithelial Cells

1Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 116001, China
2Gastrointestinal Surgery, Liaocheng City People’s Hospital, Liaocheng 252000, China
3Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China
4Graduate School, Dalian Medical University, Dalian 116044, China
5Graduate Schools, Zunyi Medical College, Zunyi 563003, China

Correspondence should be addressed to Xiaoguang Lu; moc.621@gxlld

Received 18 July 2017; Accepted 21 November 2017; Published 18 December 2017

Academic Editor: Omer Kucuk

Copyright © 2017 Xin Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Zerem, “Treatment of severe acute pancreatitis and its complications,” World Journal of Gastroenterology, vol. 20, no. 38, pp. 13879–13892, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-W. Zhang, G.-X. Zhang, H.-L. Chen et al., “Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury,” World Journal of Gastroenterology, vol. 21, no. 12, pp. 3537–3546, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. S. R. Pieczenik and J. Neustadt, “Mitochondrial dysfunction and molecular pathways of disease,” Experimental and Molecular Pathology, vol. 83, no. 1, pp. 84–92, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. K. Anand, J. Singh, A. Gaba, and S. K. Tikoo, “Effect of bovine adenovirus 3 on mitochondria.,” Veterinary Research, vol. 45, p. 45, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. D. C. Chan, “Mitochondria: dynamic organelles in disease, aging, and development,” Cell, vol. 125, no. 7, pp. 1241–1252, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C.-M. Liou, S.-C. Tsai, C.-H. Kuo, H. Ting, and S.-D. Lee, “Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse,” International Journal of Molecular Sciences, vol. 15, no. 4, pp. 5988–6001, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. O. Handa, A. Majima, Y. Onozawa et al., “The role of mitochondria-derived reactive oxygen species in the pathogenesis of non-steroidal anti-inflammatory drug-induced small intestinal injury,” Free Radical Research, vol. 48, no. 9, pp. 1095–1099, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Wu, R. Iwakiri, A. Ootani, T. Fujise, S. Tsunada, and K. Fujimoto, “Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion,” The FASEB Journal, vol. 17, no. 9, pp. 1156–1158, 2003. View at Google Scholar · View at Scopus
  9. M. V. Niklison-Chirou, F. Dupuy, L. B. Pena et al., “Microcin J25 triggers cytochrome c release through irreversible damage of mitochondrial proteins and lipids,” The International Journal of Biochemistry & Cell Biology, vol. 42, no. 2, pp. 273–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Bernardi, A. Rasola, M. Forte, and G. Lippe, “The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology,” Physiological Reviews, vol. 95, no. 4, pp. 1111–1155, 2015. View at Publisher · View at Google Scholar
  11. X. G. Lu, L. B. Zhan, X. Kang et al., “Clinical research of Dahuang Fuzi decoction in auxiliary treatment of severe acute pancreatitis: a multi-center observation in 206 patients,” Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, vol. 22, no. 12, pp. 723–728, 2010. View at Google Scholar
  12. B. Wang, G. Cheng, and F. Y. Lei, “Treatment of 36 cases of acute appendicitis by double needle with Dai Huang Fu Zi Tang,” Shaanxi Journal of Traditional Chinese Medicine, vol. 27, pp. 723-724, 2006. View at Google Scholar
  13. Y. C. Jin and H. B. Shen, “Dai Huang Fu Zi Tang treatment for 100 case report,” Journal of Hebei Traditional Chinese Medicine and Pharmacology, vol. 16, article 28, 2001. View at Google Scholar
  14. Q. H. Xu, “Early treatment of acute intra-abdominal hypertension by Dai Huang Fu Zi Tang,” Chinese Primary Health Care, vol. 26, pp. 111-112, 2012. View at Google Scholar
  15. X. Kang, X. G. Lu, L. B. Zhan et al., “Dai-Huang-Fu-Zi-Tang alleviates pulmonary and intestinal injury with severe acute pancreatitis via regulating aquaporins in rats,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, article 288, 2017. View at Publisher · View at Google Scholar
  16. H. Li, H. Guo, L. Wu et al., “Comparative pharmacokinetics study of three anthraquinones in rat plasma after oral administration of Radix et Rhei Rhizoma extract and Dahuang Fuzi Tang by high performance liquid chromatography-mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 76, pp. 215–218, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. H. J. Aho, S. M.-L. Koskensalo, and T. J. Nevalainen, “Experimental pancreatitis in the rat: Sodium taurocholate-induced acute haemorrhagic pancreatitis,” Scandinavian Journal of Gastroenterology, vol. 15, no. 4, pp. 411–416, 1980. View at Publisher · View at Google Scholar · View at Scopus
  18. C. J. Chiu, A. H. McArdle, R. Brown, H. J. Scott, and F. N. Gurd, “Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal.,” JAMA Surgery, vol. 101, no. 4, pp. 478–483, 1970. View at Publisher · View at Google Scholar · View at Scopus
  19. L. J. John, M. Fromm, and J.-D. Schulzke, “Epithelial barriers in intestinal inflammation,” Antioxidants & Redox Signaling, vol. 15, no. 5, pp. 1255–1270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. E. J. Sohn, M. J. Shin, D. W. Kim et al., “Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson's disease model,” Molecules and Cells, vol. 37, no. 3, pp. 226–233, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Bernardi and F. Di Lisa, “The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection,” Journal of Molecular and Cellular Cardiology, vol. 78, pp. 100–106, 2015. View at Publisher · View at Google Scholar
  22. P. Bernardi, “The mitochondrial permeability transition pore: a mystery solved?” Frontiers in Physiology, vol. 4, article 95, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Šileikyte, E. Blachly-Dyson, R. Sewell et al., “Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)),” The Journal of Biological Chemistry, vol. 289, no. 20, pp. 13769–13781, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. S. W. Cho, J.-S. Park, H. J. Heo et al., “Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells,” Journal of the American Heart Association, vol. 3, no. 2, Article ID e000693, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Zhao, R. Gordan, H. Wen, N. Fefelova, W.-J. Zang, and L.-H. Xie, “Modulation of intracellular calcium waves and triggered activities by mitochondrial Ca flux in mouse cardiomyocytes,” PLoS ONE, vol. 8, no. 11, Article ID e80574, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. K. N. Alavian, G. Beutner, E. Lazrove et al., “An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 111, no. 29, pp. 10580–10585, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, and F. Di Lisa, “The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ,” The Journal of Biological Chemistry, vol. 276, no. 15, pp. 12030–12034, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Budihardjo, H. Oliver, M. Lutter, X. Luo, and X. Wang, “Biochemical pathways of caspase activation during apoptosis,” Annual Review of Cell and Developmental Biology, vol. 15, pp. 269–290, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. G. D. Luk, T. M. Bayless, and S. B. Baylin, “Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity,” The Journal of Clinical Investigation, vol. 66, no. 1, pp. 66–70, 1980. View at Publisher · View at Google Scholar · View at Scopus
  30. S. M. Smith, R. H. Eng, J. M. Campos, and H. Chmel, “D-lactic acid measurements in the diagnosis of bacterial infections,” Journal of Clinical Microbiology, vol. 27, no. 3, pp. 385–388, 1989. View at Google Scholar
  31. M. J. Murray, J. J. Barbose, and C. F. Cobb, “Serum D(-)-lactate levels as a predictor of acute intestinal ischemia in a rat model,” Journal of Surgical Research, vol. 54, no. 5, pp. 507–509, 1993. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Zhao, L. Luo, W. Jia et al., “Serum diamine oxidase as a hemorrhagic shock biomarker in a rabbit model,” PLoS ONE, vol. 9, no. 8, Article ID e102285, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. X. Lu, X. Kang, L. Zhan et al., “Dai Huang Fu Zi Tang could ameliorate intestinal injury in a rat model of hemorrhagic shock by regulating intestinal blood flow and intestinal expression of p-VASP and ZO-1,” BMC Complementary and Alternative Medicine, vol. 14, article no. 80, 2014. View at Publisher · View at Google Scholar · View at Scopus