Research Article

Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Figure 2

Time-kill curves of C. albicans isolate 103 (a clinical FCZ-resistant isolate) obtained using an initial inoculum of 103 CFU/ml. The isolate was exposed to 10 μg/ml FCZ or 10 mg/ml FRC alone, or in combination. CFUs were determined after 0, 12, 24, 36, and 48 h of incubation. The mean values for log10 CFU/ml versus time in three separate experiments are shown in the plots. , log10 CFU/ml ≥ 2 antifungal activity produced by the combination compared with that of FCZ alone.