Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Table 1

Activity of FRC alone and in combination with FCZ against FCZ-resistant C. albicans  .

C. albicans	Alone		⁢Combination		FIC index for combination	Model of interaction
	FRC	FCZ	FRC	FCZ
100	39.06	>64	4.88	0.125	0.126	syn
904	19.53	>64	4.88	0.125	0.25	syn
953	19.53	>64	4.88	0.125	0.25	syn
901	312.5	>64	2.44	1	0.016	syn
103	19.53	>64	2.44	0.125	0.126	syn
J5	19.53	>64	4.88	2	0.265	syn
32	19.53	>64	4.88	2	0.265	syn
842	19.53	>64	4.88	8	0.312	syn
557	19.53	>64	1.22	8	0.125	syn
J28	39.06	>64	4.88	1	0.133	syn
J38	39.06	>64	4.88	0.125	0.126	syn
112678#	19.53	>64	1.22	2	0.078	syn
502	39.06	>64	2.44	1	0.070	syn

, fluconazole; FRC, Flos Rosae Chinensis; FIC index, fractional inhibitory concentration index; syn, synergism.
values for combinations are expressed as MIC₈₀ of FCZ/MIC₈₀ of FRC. High off-scale MIC₈₀ values were converted to the next highest concentration.
and antagonism were defined by FIC indices of <0.5 and >4, respectively. An FIC index result of >0.5 but <4 was considered indifferent.