Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Table 2

Activity of FRC alone and in combination with FCZ against FCZ-sensitive C. albicans  .

C. albicans	Alone		⁢Combination		FIC index for combination	Model of interaction
	FRC	FCZ	FRC	FCZ
SC5314	19.53	1	2.44	1	1.125	indiff
AT10231	19.53	0.5	4.88	0.25	0.750	indiff
465	39.06	0.5	4.88	0.25	0.625	indiff
113187#	19.53	2	2.44	1	0.625	indiff
112721#	19.53	2	4.88	1	0.750	indiff

, fluconazole; FRC, Flos Rosae Chinensis; FIC index, fractional inhibitory concentration index; indiff, indifference.
values for combinations are expressed as MIC₈₀ of FCZ/MIC₈₀ of FRC. High off-scale MIC₈₀ values were converted to the next highest concentration.
and antagonism were defined by FIC indices of <0.5 and >4, respectively. An FIC index result of >0.5 but <4 was considered indifferent.