Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Table 3

Activity of FRC alone and in combination with FCZ against other fungi .

Fungi	Alone		Combination		FIC index for combination	Model of interaction
	FRC	FCZ	FRC	FCZ
C. krusei 4996	19.53	64	4.88	>64	2.25	indiff
C. tropicalis 2718	78.125	64	4.88	0.25	0.066	indiff
C. parapsilosis 90018	4.88	0.5	2.44	0.25	1	indiff
C. parapsilosis 160	156.25	0.5	19.53	0.125	0.375	syn
Aspergillus fumigatus 7544	>10000	>64	156.25	>64	1.008	indiff
M. gypseum	625	32	19.53	0.125	0.035	syn
T. rubrum	312.5	16	19.53	0.125	0.07	syn

, fluconazole; FRC, Flos Rosae Chinensis; FIC index, fractional inhibitory concentration index; syn, synergism; indiff, indifference.
values for combinations are expressed as MIC₈₀ of FCZ/MIC₈₀ of FRC. High off-scale MIC₈₀ values were converted to the next highest concentration.
and antagonism were defined by FIC indices of <0.5 and >4, respectively. An FIC index result of >0.5 but <4 was considered indifferent.