Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Table 4

Activity of FRC alone and in combination with other antifungal drugs against FCZ-resistant C. albicans  .

Positive drug	Alone		Combination		FIC index for combination	Model of interaction	C. albicans
	FRC	Positive drug	FRC	Positive drug
MCZ	39.06	64	2.44	0.125	0.064	syn	J5
MCZ	312.5	64	2.44	0.125	0.01	syn	901
MCZ	39.06	64	2.44	0.125	0.064	syn	103
KCZ	39.06	32	2.44	0.125	0.066	syn	J5
KCZ	312.5	32	2.44	0.125	0.012	syn	901
KCZ	39.06	32	2.44	0.125	0.066	syn	103
ICZ	39.06	>64	2.44	0.125	0.063	syn	J5
ICZ	312.5	>64	2.44	0.5	0.012	syn	901
ICZ	39.06	>64	2.44	0.25	0.064	syn	103
5-FLU	39.06	0.016	2.44	0.016	1.062	indiff	J5
5-FLU	312.5	0.25	39.06	0.125	0.625	indiff	901
5-FLU	19.53	0.25	1.22	0.25	1.062	indiff	103
AMB	39.06	0.5	4.88	0.5	1.125	indiff	J5
AMB	312.5	0.25	78.125	0.125	0.75	indiff	901
AMB	19.53	0.5	4.88	0.25	0.75	indiff	103

, ketoconazole; ICZ, itraconazole; MCZ, miconazole; 5-Fc, 5-fluorocytosine; AMB, amphotericin B; FRC, Flos Rosae Chinensis; FIC index, fractional inhibitory concentration index; syn, synergism; indiff, indifference.
values for combinations are expressed as MIC₈₀ of FCZ/MIC₈₀ of FRC. High off-scale MIC₈₀ values were converted to the next highest concentration.
and antagonism were defined by FIC indices of <0.5 and >4, respectively. An FIC index result of >0.5 but <4 was considered indifferent.