Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida

Table 7

Sterol compositions of C. albicans strain 103 following FCZ or FRC treatment, as analyzed by gas chromatography-mass .

	Control	FCZ; 1 µg/ml	FCZ; 1 µg/ml + FRC 25 µg/ml	FCZ; 1 µg/ml + FRC 250 µg/ml	FCZ; 1 µg/ml + FRC 2.5 mg/ml	FRC; 2.5 mg/ml
Ergosterol	87.8	8.93	8.38	1.81	1.72	21.75
14a-Methyl-5a-ergosta-8,24(28)-dien-3a-ol	ND	3.2	2.87	ND	ND	ND
Ergosta-8,24(28)-dien-3-ol,4,14-dimethyl	1.76	6.45	27.12	2.36	2.02	8.78
Stigmast-5-en-3-ol	ND	ND	1.21	12.28	11.26	8.05
Eburicol	ND	55.54	55.9	70.83	72.93	56.03
Cholest-4-en-3-one	ND	ND	ND	0.7	0.34	ND
Lanosterol	ND	25.22	ND	9.05	9.99	ND
Ergosta-7,22-dien-3-ol	1.27	ND	ND	ND	ND	0.69
Ergosta-5,8-dien-3-ol	1.81	ND	ND	ND	ND	2.35
Cholest-7-en-3-one,4,4-dimethyl-	ND	3.2	ND	ND	ND	ND
Cholesta-8,24-dien-3-ol,(3á,5à)-(zymosterol)	1.26	ND	ND	ND	ND	ND
Ergosta-5,24(28)-dien-3-ol	1.12	0.65	3.97	2.07	1.14	0.86
Cholest-7-en-3-ol,4,4-dimethyl-	1.05	ND	ND	ND	ND	0.95
Unknown	3.93	ND	ND	ND	ND	ND
Ergost-5-en-3-ol	ND	ND	ND	0.9	0.6	0.55

, fluconazole; FRC, Flos Rosae Chinensis; ND, not detected.