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Number | Author | Study design | Control group | Experimental group | Outcome | Results |
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(1) | Choi et al. [6] | In vivo: KM mice | Normal ()
| EID + TCM | Pregnancy rate | EID + TCM versus EID: ↑ () |
Implantation sites | EID + TCM versus EID: ↑ () |
LIF mRNA | EID + TCM versus EID on Pd 4, 6: ↑ () EID + TCM versus EID on Pd 5 ↓ () EID + TCM versus normal: not significant () |
LIF protein | EID + TCM versus Normal on Pd 6: not significant EID versus EID + TCM: ↓ () EID versus normal: ↓ () |
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(2) | Xu et al. [10] | In vivo: KM mice | Normal () EID† EID + Progynova () | EID + TCM (0.91 g/Kg) () EID + TCM (1.82 g/Kg) () EID + TCM (3.64 g/Kg) () | PPARd, IL-11 mRNA | TCM at doses of 1.82 g/kg, 3.64 g/kg versus progynova: ↑ () |
COX-2 | In gland | EID + TCM, EID + Progynova versus EID: ↑ () EID + TCM versus Progynova: ↑ () |
In stroma | not significant () |
PGI2 | In gland | EID + TCM, EID + Progynova versus EID: ↑ () EID + TCM at high doses versus EID + Progynova: ↑ () |
In stroma | EID + TCM versus EID: ↑ () |
MMP-9 | In gland | EID + TCM, EID + Progynova versus EID: ↑ () |
In stroma | EID + TCM, EID + Progynova versus EID: ↑ () |
TIMP-3 | In gland | EID + TCM, EID + Progynova versus EID: ↑ () EID + TCM at high dose versus EID + Progynova: ↑ () |
In stroma | not significant () |
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(3) | Cui et al. [14] | In vivo: KM mice | Normal () COH‡
| COH + TCM (BS) () COH + TCM (HX) () COH + TCM (BH) () | Endometrial thickness | COH + , COH + HX∥, COH + BH versus COH: ↑ (, <0.0001, <0.0001) COH + BH vs COH + : ↑ () |
Microvessel density | COH + , COH + HX∥, COH + versus COH: ↑ (, 0.0003, 0.0004) |
Pinopodes in the epithelium | COH + HX∥, COH + BH versus COH: ↑ (, 0.0009) COH + HX∥, COH + BH versus COH + : ↑ (, 0.033) |
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(4) | Huang et al. [11] | In vivo: KM mice | Normal ()
| EID + TCM | Pregnancy rate | EID + TCM versus EID: ↑ () |
Number of implanted blastocysts | EID + TCM versus EID: ↑ () |
Proliferative index | In gland | EID + TCM versus EID: ↓ () EID + TCM versus normal: not significant () |
Proliferative index | In stroma | not significant () |
Apoptotic index | In gland | EID + TCM versus EID: ↑ () EID + TCM versus normal: not significant () |
Apoptotic index | In stroma | not significant () |
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(5) | Sun et al. [15] | In vivo: KM mice | Normal () COH‡
| COH + TCM () | Integrin β3 mRNA | COH + TCM versus COH on Pd 2, 4: ↓ () Among 3 groups on Pd 0, 6, 8: not significant () |
OPN mRNA | COH + TCM versus COH on Pd 4, 6, 8: ↓ () Among 3 groups on Pd 0, 2: not significant () |
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(6) | Chen et al. [16] | In vivo: KM mice | Normal () COH‡ + aspirin | COH + TCM () | Integrin β3 mRNA | COH + TCM versus aspirin: ↑ () |
LIF mRNA/β-actin | COH + TCM versus aspirin: ↑ () |
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(7) | Yu et al. [18] | In vivo: KM mice | Normal () COH‡
| TCM COH + TCM EID + TCM | Pregnancy rate | COH + TCM versus COH: ↑ () EID + TCM versus EID: ↑ () TCM versus normal: not significant difference () |
Implantation sites | TCM versus EID: ↑ () EID + TCM versus EID: ↑ () |
LIF proteins | TCM versus COH, EID: ↑ (, ) |
Integrin β3 proteins | COH + TCM, EID + TCM versus COH, EID: ↑ (, ) |
LIF mRNA | TCM versus COH + TCM: ↑ () TCM versus EID + TCM: ↑ () |
Integrin β3 mRNA | TCM versus COH + TCM: ↑ () TCM versus EID + TCM: ↑ () |
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(8) | Li et al. [12] | In vivo: KM mice | Normal ()
| COH + TCM () | LCM-DE-MS†† | COH + TCM group showed significant changes in 23 proteins: 7 proteins downregulated‡‡ and 16 proteins up |
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(9) | Wu et al. [13] | In vivo: KM mice | Normal ()
| EID + TCM | Pregnancy rate | EID + TCM versus EID: ↑ () EID + TCM versus normal: ↓ () |
Number of Implanted embryos | EID + TCM versus EID: not significant () EID + TCM versus normal: ↓ () |
NF-κВ | EID versus Normal on Pd 5, 6, 7: ↑ () EID versus EID + TCM on Pd 5, 6, 7: ↑ () EID + TCM versus normal during whole time: not significant () |
IFN-γ, IL-10 | EID + TCM versus normal: not significant () EID + TCM versus EID on Pd 5, 6, 7: ↑ () |
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(10) | Choi et al. [9] | In vitro: Ishikawa cells | | | LIF mRNA | PL-PP group showed significant increase dose-dependently () |
Adhesion of JAr spheroids | PL-PP versus Control: ↑ () |
In vivo: KM mice | Normal ()
| EID + PL-PP () | No of implanted embryos | PL-PP versus RU486: ↑ () PL-PP versus normal: ↑ () |
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(11) | Li et al. [17] | In vivo: KM mice | Normal () COH‡
| TCM () | Number of implanted blastocyst | TCM + model versus model: ↑ () |
Integrin α mRNA | Model versus TCM, control: ↓ () |
Integrin β3 mRNA | Model versus TCM, control: ↓ () |
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