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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 4837839, 9 pages
Research Article

Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice

1College of Chemistry, Fuzhou University, Fuzhou 350116, China
2Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China

Correspondence should be addressed to Feng Li; moc.nuyila@6769gnefil and Yanghao Guo; moc.nuyila@ougoahgnay

Received 20 December 2016; Accepted 13 February 2017; Published 16 March 2017

Academic Editor: Ken Yasukawa

Copyright © 2017 Feng Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The interest focusing on Eriobotrya japonica leaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g·kg−1 body weight) and subacute (150, 300, and 600 mg·kg−1 BW) 28-day toxicity studies. Because of lacking apparently adverse effects found in the hematology, clinical biochemistry, and histopathology evaluation, results of the present study together with the beneficial effects make ELTA as a promising dietary supplement and indicated that ELTA administered orally might have a large safety margin for human.