Research Article
QGQS Granule in SHR Serum Metabonomics Study Based on Tools of UPLC-Q-TOF and Renin-Angiotensin-Aldosterone System Form Protein Profilin-1
Table 1
UPLC-Q-TOF indicated metabolites and potential pathway analysis.
| | Number | (min) | | VIP | value | Formula | Indicated metabolites | Pathway |
| | (1) | 0.37 | 175.0282 | 2.32 | 0.00001 | C6H8N2O2 | Methylimidazoleacetic acid | Histidine metabolism | | (2) | 0.64 | 167.0938 | 2.9 | 0.0001 | C7H16 | Acetylcholine | Acetylcholine synthesis | | (3) | 1.31 | 212.0549 | 2.02 | 0.0002 | C9H13NO6 | N2-Succinyl-L-glutamic acid 5-semialdehyde | Arginine and proline metabolism | | (4) | 2.22 | 498.3017 | 3.27 | 0.014 | C26H48NO7P | LysoPC (18:3) | Glycerophospholipid metabolism | | (5) | 2.26 | 514.2937 | 5.72 | 0.001 | C24H48NO7P | LysoPC (16:1) | Glycerophospholipid metabolism | | (6) | 2.59 | 860.6016 | 1.44 | 0.0001 | C47H88NO8P | PE (24:0/18:3) | Glycerophospholipid metabolism | | (7) | 4.16 | 619.4636 | 1.64 | 0.005 | C36H62O5 | DG (15:0/18:4/0:0) | Diacylglycerol metabolize | | (8) | 4.19 | 1138.4354 | 1.04 | 0.001 | C45H82N7O17P3S | Tetracosanoyl-CoA | Biosynthesis of unsaturated fatty acids | | (9) | 4.24 | 500.2908 | 2.13 | 0.0001 | C23H48NO6P | PC (P-15:0/0:0) | Glycerophospholipid metabolism | | (10) | 4.48 | 660.2416 | 1.82 | 0.0002 | C30H45N3O9S | Leukotriene C5 | Arachidonic acid metabolism | | (11) | 4.7 | 353.2345 | 2.26 | 0.0001 | C20H34O5 | Prostaglandin H1 | Prostaglandin synthesis and regulation | | (12) | 4.82 | 592.2889 | 1.89 | 0.0001 | C26H46NO9P | PS (20:3/0:0) | Glycerophospholipid metabolism | | (13) | 4.87 | 353.2461 | 1.29 | 0.0002 | C22H36O2 | Adrenic acid | Biosynthesis of unsaturated fatty acids | | (14) | 5.13 | 583.3287 | 1.28 | 0.0001 | C27H53O11P | PI (18:0/0:0) | Glycerophospholipid metabolism | | (15) | 7.3 | 799.5952 | 1.24 | 0.004 | C43H83N2O6P | SM (d18:0/20:2) | Sphingolipid metabolism | | (16) | 8.83 | 129.0020 | 1.6 | 0.0001 | C5H8O3S | 2-Oxo-4-methylthio-butanoic acid | Methionine metabolism | | (17) | 11.27 | 779.5189 | 1.25 | 0.0001 | C40H77NO11S | 3-O-Sulfogalactosylceramide (d18:1/16:0) | Sphingolipid metabolism | | (18) | 11.88 | 479.2471 | 2.66 | 0.0001 | C24H40O6S | Lithocholic acid sulfate | Biological oxidations | | (19) | 13.44 | 237.1266 | 1.14 | 0.06 | C19H26O2 | Dodecanoic acid | Fatty acid biosynthesis | | (20) | 14.9 | 595.3736 | 2.44 | 0.0003 | C19H26O2 | Androstenedione | Steroid biosynthesis |
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