In Vivo and In Vitro Evaluation of Pharmacological Potentials of Secondary Bioactive Metabolites of Dalbergia candenatensis Leaves

Table 4

Anti-inflammatory activity of D. candenatensis on formaldehyde-induced subacute inflammation in rat (mean ± SEM, ). See supplementary data associated with this table.

Groups	Dose; (mg/kg)	Mean difference in paw diameter; (% inhibition)
		1 hr	2 hr	3 hr	4 hr	24 hr	48 hr
Control (1% v/v Tween-80 water)	10 ml/kg	1.10 ± 0.0071	1.25 ± 0.006	1.28 ± 0.004	1.33 ± 0.011	1.30 ± 0.014	1.26 ± 0.011
Indomethacin	10 mg/kg	0.82 ± 0.007; (24.4%)	0.85 ± 0.004; (32%)	0.45 ± 0.008; (64.84%)	0.51 ± 0.007; (61.65%)	0.57 ± 0.009; (56.15%)	0.61 ± 0.01; (51.5%)
Extract I	100 mg/kg	1.05 ± 0.007; (4.5%)	1.18 ± 0.007; (5.6%)	1.04 ± 0.01; (18.75%)	1.11 ± 0.007; (16.54%)	1.08 ± 0.009; (16.92%)	1.08 ± 0.008; (14.2)
Extract II	250 mg/kg	1.01 ± 0.011; (8.18%)	1.11 ± 0.007; (11.2%)	0.92 ± 0.009; (28.12%)	0.98 ± 0.007; (26.71%)	0.97 ± 0.08; (25.38%)	0.95 ± 0.01; (24.6%)
Extract II	500 mg/kg	0.97 ± 0.007; (11.8%)	1.08 ± 0.006; (13.6%)	0.81 ± 0.005; (36.71%)	0.84 ± 0.011; (36.84%)	0.84 ± 0.005; (35.38%)	0.82 ± 0.009; (34.9%)

indicates when compared with control.