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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 5076029, 13 pages
Research Article

Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro

1Herbal Technology Section (HTS), Modern Research & Development Complex (MRDC), Industrial Technology Institute (ITI), 503A Halbarawa Gardens, Malabe, Sri Lanka
2Department of Zoology, Faculty of Science, University of Colombo, Colombo, Sri Lanka
3Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka

Correspondence should be addressed to Sirimal Premakumara Galbada Arachchige

Received 3 June 2017; Revised 25 July 2017; Accepted 3 August 2017; Published 30 August 2017

Academic Editor: Luigi Milella

Copyright © 2017 Sirimal Premakumara Galbada Arachchige et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ethanol (95%) and dichloromethane : methanol (DCM : M, 1 : 1 v/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin- (BSA-) glucose and BSA-methylglyoxal models in vitro. Further, total proanthocyanidins (TP) were quantified. Results showed significant differences () between bark and leaf extracts for the studied biological activities (except antiglucosidase) and TP. BEs showed significantly high () activities for antiamylase (IC50: μg/mL), antibutyrylcholinesterase (IC50: μg/mL), and glycation reversing in BSA-glucose model (EC50: μg/mL) compared to LEs. In contrast, glycation reversing in BSA-methylglyoxal (EC50: ethanol: μg/mL) and antiglycation in both BSA-glucose (IC50: ethanol: μg/mL) and BSA-methylglyoxal models (IC50: DCM : M: μg/mL) were significantly high () in leaf. Compared to the reference drugs used some of the biological activities were significantly () high (BEs: BChE inhibition and ethanol leaf: BSA-glucose mediated antiglycation), some were comparable (BEs: BSA-glucose mediated antiglycation), and some were moderate (BEs and LEs: antiamylase, AChE inhibition, and BSA-MGO mediated antiglycation; DCM : M leaf: BSA-glucose mediated antiglycation). TP were significantly high () in BEs compared to LEs (BEs and LEs: and  mg cyanidin equivalents/g extract, resp.). In conclusion, both bark and leaf of CC possess antidiabetic properties and thus may be useful in managing diabetes and its complications.