Research Article

Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro

Table 1

Antidiabetic activity of Cinnamomum species in vitro.

Cinnamomum speciesPart used/extractActivityReferences

Antiamylase activity
C. zeylanicum Bark aqueous extractIC50: 1.23 ± 0.02 mg/mLAdisakwattana et al., 2011 [18]
C. aromaticum (cassia)Bark aqueous extractIC50: 1.77± 0.05 mg/mLAdisakwattana et al., 2011 [18]
C. loureiroi (Saigon cinnamon)Bark aqueous extractIC50: >4.00 mg/mLAdisakwattana et al., 2011 [18]
C. zeylanicum (C. verum) Bark hydro alcoholic extract (50 : 50; v/v, water ethanol)IC50: 25 µg/mLBeejmohun et al., 2014 [19]
C. verumIsopropanol leaf extractIC50: 1 µg/mLPonnusamy et al. 2011 [20]
C. zeylanicum Bark aqueous extract77% inhibition at 25 mg/mL; 72% inhibition at 12.5 mg/mL and 51% inhibition at 5 mg/mLRanilla et al., 2010 [21]

Antiglucosidase activity/maltase and sucrase inhibition
C. zeylanicum Bark aqueous extract100% and 95% inhibition at 2.5 and 0.5 mg/mL, respectivelyRanilla et al., 2010 [21]
C. zeylanicum Bark aqueous extractIC50  µg/mL: 0.77 ± 0.04 maltase; 0.42 ± 0.02 sucraseAdisakwattana et al., 2011 [18]
C. aromaticum (cassia)Bark aqueous extractIC50  µg/mL: 0.85 ± 0.04 maltase; 0.88 ± 0.33 sucraseAdisakwattana et al., 2011 [18]
C. loureiroi (Saigon cinnamon)Bark aqueous extractIC50  µg/mL: 0.96 ± 0.03 maltase; >4.00 sucraseAdisakwattana et al., 2011 [18]

Antiglycation activity
Cinnamon (Cinnamomum species used not mentioned)Ethyl acetate and butanol soluble fractions of bark water extract diluted with ethanolBSA-glucose antiglycation : ethyl acetate soluble fractions: >40% to <90% inhibition at 200 ppm; butanol soluble fractions: <10% to >80% inhibition at 200 ppm
BSA-MGO antiglycation: ethyl acetate soluble fractions: <10% to <80% inhibition at 2.5 mg/mL; butanol soluble fractions: <10% to nearly 40% inhibition at 2.5 mg/mL
Peng et al., 2008 [22]
C. verum Bark methanol extractBSA-glucose antiglycation: IC50: 26 µg/mLHo and Chang, 2012 [23]

AChE and BChE inhibitory activity
C. zeylanicumBark ethanol extractAChE: 40.83 ± 0.005 % inhibition at 100 µg/mL; BChE: 51.53 ± 0.005 % inhibition at 100 µg/mLKumar et al., 2012 [24]
C. zeylanicumMethanolic leaf extractIC50: AChE 77.78 ± 0.03 µg/mL; BChE 88.62 ± 1.72 µg/mLDalai et al., 2014 [25]

Experimental cinnamon sample has no authentication; AChE: acetylcholinesterase; BChE: butyrylcholinesterase.