Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice

Figure 2

Mean seizure score in the experimental groups. Mice were injected with PTZ (35 mg/kg) trice a week for a total of 13 injections. Seizures were scored (0) if there is no seizure response, (1) if immobility, eye closure, ear twitching, or facial clonus appears, (2) if head nodding associated with more severe facial clonus, (3) if there is clonus of one forelimb, (3, 5) if there is bilateral forelimb clonus without rearing, (4) if there is bilateral forelimb clonus with rearing, (4, 5) if animals fall on a side (without rearing), loss of righting reflex with generalized tonic-clonic seizures, and (5) if rearing and falling on back occur accompanied by generalized tonic-clonic seizures. Results are mean ± SEM and analyzed using one-way ANOVA followed by Bonferroni’s post hoc test at . difference from saline group. difference from PTZ group. difference from PTZ + P. austroarabica extract (200 mg/kg) group, = 4–6.