Tang-Luo-Ning, a Traditional Chinese Medicine, Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis of Schwann Cells under High Glucose Environment
TLN can decrease the expression of GADD34 and Ero1α and increase the expression of P-eIF2α in high glucose-induced RSC96 cells. (a) Images of GADD34 relative protein level measured by high content analysis; images were viewed at a magnification of 10x. (b) Images of Ero1α and P-eIF2α relative protein level measured by Western blot, normalized to β-actin. ((c)–(e)) Summarized data of GADD34, Ero1α, and P-eIF2α, normalized as fold change of 25 mM glucose group. Data were analyzed by one-way ANOVA followed by least significant difference. Data were shown as mean ± SEM (). and versus 25 mM glucose; and versus 150 mM glucose.
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