Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 5294890, 15 pages
https://doi.org/10.1155/2017/5294890
Research Article

A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer

1O&T Department, Queen Elizabeth Hospital, Kowloon, Hong Kong
2Department of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong
3School of Nursing, Tung Wah College, Kowloon, Hong Kong
4Department of Health Technology & Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong
5Faculty of Liberal Arts and Social Sciences, The Education University of Hong Kong, Tai Po, Hong Kong
6Ginger Knowledge Transfer and Consultancy Limited, Kowloon, Hong Kong

Correspondence should be addressed to Ka-Kit Tsang; moc.rotagivten@3gnastkk

Received 25 September 2016; Revised 3 December 2016; Accepted 13 December 2016; Published 25 January 2017

Academic Editor: Elia Ranzato

Copyright © 2017 Ka-Kit Tsang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. R. Martínez-De Jesús, “A checklist system to score healing progress of diabetic foot ulcers,” International Journal of Lower Extremity Wounds, vol. 9, no. 2, pp. 74–83, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. International Diabetes Federation, IDF Diabetes Atlas, IDF, Brussels, Belgium, 6th edition, 2013.
  3. Y.-J. Chu, X.-W. Li, P.-H. Wang et al., “Clinical outcomes of toe amputation in patients with type 2 diabetes in Tianjin, China,” International Wound Journal, vol. 13, no. 2, pp. 175–181, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. B. A. Lipsky, E. J. G. Peters, A. R. Berendt et al., “Specific guidelines for the treatment of diabetic foot infections 2011,” Diabetes/Metabolism Research and Reviews, vol. 28, S1, pp. 234–235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. A. J. van den Berg, E. van den Worm, H. C. Q. van Ufford, S. B. Halkes, M. J. Hoekstra, and C. J. Beukelman, “An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey,” Journal of Wound Care, vol. 17, no. 4, pp. 172–178, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. G. Sibbald and K. Y. Woo, “The biology of chronic foot ulcers in persons with diabetes,” Diabetes/Metabolism Research and Reviews, vol. 24, no. 1, pp. S25–S30, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. L. Sare, “Leg ulcer management with topical medical honey,” British Journal of Community Nursing, vol. 13, no. 9, pp. S22–S26, 2008. View at Google Scholar · View at Scopus
  8. I. Sondi and B. Salopek-Sondi, “Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria,” Journal of Colloid & Interface Science, vol. 275, no. 1, pp. 177–182, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. K. M. Aparna Mani, S. Seethalakshmi, and V. Gopal, “Evaluation of in-vitro anti-inflammatory activity of silver nanoparticles synthesised using piper nigrum extract,” Nanomedicine & Nanotechnology, vol. 6, article 268, 2015. View at Publisher · View at Google Scholar
  10. J. Stephen-Haynes, “Evaluation of a honey-impregnated tulle dressing in primary care,” British Journal of Community Nursing, pp. S21–S27, 2004. View at Google Scholar · View at Scopus
  11. M. D. Mandal and S. Mandal, “Honey: its medicinal property and antibacterial activity,” Asian Pacific Journal of Tropical Biomedicine, vol. 1, no. 2, pp. 154–160, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. C. J. Adams, C. H. Boult, B. J. Deadman et al., “Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey,” Carbohydrate Research, vol. 343, no. 4, pp. 651–659, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. P. H. S. Kwakman, A. A. te Velde, L. de Boer, C. M. J. E. Vandenbroucke-Grauls, and S. A. J. Zaat, “Two major medicinal honeys have different mechanisms of bactericidal activity,” PLoS ONE, vol. 6, no. 3, Article ID e17709, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Kato, N. Umeda, A. Maeda, D. Matsumoto, N. Kitamoto, and H. Kikuzaki, “Identification of a novel glycoside, leptosin, as a chemical marker of manuka honey,” Journal of Agricultural and Food Chemistry, vol. 60, no. 13, pp. 3418–3423, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. C. W. Chan, B. J. Deadman, M. Manley-Harris, A. L. Wilkins, D. G. Alber, and E. Harry, “Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole,” Food Chemistry, vol. 141, no. 3, pp. 1772–1781, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Al Saeed, “Therapeutic Efficacy of conventional treatment combined with manuka honey in the treatment of patients with diabetic foot ulcers: a randomized controlled study,” The Egyptian Journal of Hospital Medicine, vol. 53, pp. 1064–1071, 2013. View at Publisher · View at Google Scholar
  17. A. V. Kamaratos, K. N. Tzirogiannis, S. A. Iraklianou, G. I. Panoutsopoulos, I. E. Kanellos, and A. I. Melidonis, “Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers,” International Wound Journal, vol. 11, no. 3, pp. 259–263, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Cahn and Y. Kleinman, “A novel approach to the treatment of diabetic foot abscesses—a case series,” Journal of Wound Care, vol. 23, no. 8, pp. 394–399, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. B. A. Lipsky, A. R. Berendt, P. B. Cornia et al., “2012 infectious diseases society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections,” Clinical Infectious Diseases, vol. 54, no. 12, pp. e132–e173, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Hertzog, “Considerations in determining sample size for pilot studies,” Research in Nursing and Health, vol. 31, no. 2, pp. 180–191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. C. A. Fries, Y. Ayalew, J. G. Penn-Barwell, K. Porter, S. L. A. Jeffery, and M. J. Midwinter, “Prospective randomised controlled trial of nanocrystalline silver dressing versus plain gauze as the initial post-debridement management of military wounds on wound microbiology and healing,” Injury, vol. 45, no. 7, pp. 1111–1116, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Gottrup, B. M. Cullen, T. Karlsmark, M. Bischoff-Mikkelsen, L. Nisbet, and M. C. Gibson, “Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment,” Wound Repair and Regeneration, vol. 21, no. 2, pp. 216–225, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. C. N. Miller, N. Newall, S. E. Kapp et al., “A randomized-controlled trial comparing cadexomer iodine and nanocrystalline silver on the healing of leg ulcers,” Wound Repair & Regeneration, vol. 18, no. 4, pp. 359–367, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. W. White, “Sharp wound debridement in the management of recalcitrant, locally infected chronic venous leg ulcers: a narrative review,” Wound Practice and Research, vol. 19, no. 4, 2011. View at Google Scholar
  25. C. E. Bradshaw, “An in vitro comparison of the antimicrobial activity of honey, iodine and silver wound dressings,” Bioscience Horizons, vol. 4, no. 1, pp. 61–70, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. D. G. Metcalf and P. G. Bowler, “Biofilm delays wound healing: a review of the evidence,” Burns & Trauma, vol. 1, no. 1, pp. 5–12, 2013. View at Publisher · View at Google Scholar
  27. E. A. Rayment, Z. Upton, and G. K. Shooter, “Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer,” The British Journal of Dermatology, vol. 158, no. 5, pp. 951–961, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Moore, E. Huddleston, M. C. Stacey, and K. G. Harding, “Venous leg ulcers—the search for a prognostic indicator,” International Wound Journal, vol. 4, no. 2, pp. 163–172, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. A. D. Widgerow, “Chronic wound fluid—thinking outside the box,” Wound Repair and Regeneration, vol. 19, no. 3, pp. 287–291, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. E. A. Rayment, T. R. Dargaville, G. K. Shooter, G. A. George, and Z. Upton, “Attenuation of protease activity in chronic wound fluid with bisphosphonate-functionalised hydrogels,” Biomaterials, vol. 29, no. 12, pp. 1785–1795, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Cullen, R. Smith, E. Mcculloch, D. Silcock, and L. Morrison, “Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers,” Wound Repair & Regeneration, vol. 10, no. 1, pp. 16–25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Bahar-Shany, A. Ravid, and R. Koren, “Upregulation of MMP-9 production by TNFα in keratinocytes and its attenuation by vitamin D,” Journal of Cellular Physiology, vol. 222, no. 3, pp. 729–737, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S. J. M. Yussof, E. Omar, D. R. Pai, and S. Sood, “Cellular events and biomarkers of wound healing,” Indian Journal of Plastic Surgery, vol. 45, no. 2, pp. 220–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. R. F. Diegelmann and M. C. Evans, “Wound healing: an overview of acute, fibrotic and delayed healing,” Frontiers in Bioscience, vol. 9, pp. 283–289, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. N. J. Trengove, H. Bielefeldt-Ohmann, and M. C. Stacey, “Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers,” Wound Repair & Regeneration, vol. 8, no. 1, pp. 13–25, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Moseley, J. R. Hilton, R. J. Waddington, K. G. Harding, P. Stephens, and D. W. Thomas, “Comparison of oxidative stress biomarker profiles between acute and chronic wound environments,” Wound Repair & Regeneration, vol. 12, no. 4, pp. 419–429, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, and H. Lehnert, “Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients,” Diabetologia, vol. 45, no. 7, pp. 1011–1016, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Muller, C. Trocme, B. Lardy, F. Morel, S. Halimi, and P. Y. Benhamou, “Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing,” Diabetic Medicine, vol. 25, no. 4, pp. 419–426, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Liu, D. Min, T. Bolton et al., “Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers: response to Muller et al.,” Diabetes Care, vol. 32, no. 11, p. e137, 2009. View at Publisher · View at Google Scholar · View at Scopus