Genome-Wide Profiling Reveals That Herbal Medicine Jinfukang-Induced Polyadenylation Alteration Is Involved in Anti-Lung Cancer Activity

Figure 1

Treatment with JFK induced cell death in A549 cells. (a) Inhibitory effect of JFK on viability of A549 cells. A549 cells were treated with JFK (30 μg/ml, 45 μg/ml, 60 μg/ml, 90 μg/ml, 120 μg/ml, 150 μg/ml, and 200 μg/ml, resp.) for 24 h; the viable cells were determined by CCK8 assay. (b) Observation of A549 cells under optical microscope and fluorescence microscope stained with PI for detecting dead cells. Scale bar: 50 μm. (c) A549 cells were treated with JFK, and the apoptotic progression was determined by flow cytometry. Values in (a) represent means ± SE of data from three independent experiments, .

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