Total Coumarins from<i> Hydrangea paniculata</i> Protect against Cisplatin-Induced Acute Kidney Damage in Mice by Suppressing Renal Inflammation and Apoptosis

<div>Effect of HP on cisplatin affected renal tissues of mice by light microscopic examination (H&amp;E). (a) Normal group and (b) cisplatin-treated group have severe tubular damage with acute tubular necrosis (dashed thick arrow), wide tubular epithelial vacuolation, apoptotic tubular epithelium, and cast formation (star, *). (c) HP with 20 mg/kg and (d) HP with 40 mg/kg and cisplatin-treated group showed significantly less impaired renal tubules with minimal focal vacuolation of the tubular epithelium. (e) HP treated alone group showed normal nonaffected tubular epithelium. (f) Renal injury score. Each renal injury score value represents the mean of six mice. All the pictures were taken under 200x magnification.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Total Coumarins from<i> Hydrangea paniculata</i> Protect against Cisplatin-Induced Acute Kidney Damage in Mice by Suppressing Renal Inflammation and Apoptosis 

Figure 3 | Total Coumarins from Hydrangea paniculata Protect against Cisplatin-Induced Acute Kidney Damage in Mice by Suppressing Renal Inflammation and Apoptosis 