Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 5469125, 10 pages
https://doi.org/10.1155/2017/5469125
Research Article

Therapeutic Effects of Fermented Flax Seed Oil on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

1Department of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dongguk University, Dongguk-ro 27, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea
2Department of Pediatrics, College of Korean Medicine, Dongguk University, Dongguk-ro 27, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea

Correspondence should be addressed to Seungug Hong; moc.revan@ushtneeh

Received 17 October 2016; Revised 29 November 2016; Accepted 14 December 2016; Published 19 January 2017

Academic Editor: Isabel Andújar

Copyright © 2017 Joonhyoung Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Kay, D. J. Gawkrodger, M. J. Mortimer, and A. G. Jaron, “The prevalence of childhood atopic eczema in a general population,” Journal of the American Academy of Dermatology, vol. 30, no. 1, pp. 35–39, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Shamssain, “Trends in the prevalence and severity of asthma, rhinitis and atopic eczema in 6- to 7- and 13- to 14-yr-old children from the north-east of England,” Pediatric Allergy and Immunology, vol. 18, no. 2, pp. 149–153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Zheng, J. Yu, M. H. Oh, and Z. Zhu, “The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma,” Allergy, Asthma & Immunology Research, vol. 3, no. 2, pp. 67–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. Cork, S. G. Danby, Y. Vasilopoulos et al., “Epidermal barrier dysfunction in atopic dermatitis,” Journal of Investigative Dermatology, vol. 129, no. 8, pp. 1892–1908, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Boguniewicz and D. Y. M. Leung, “The ABC's of managing patients with severe atopic dermatitis,” The Journal of Allergy and Clinical Immunology, vol. 132, no. 2, pp. 511–512, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Y. M. Leung and E. Guttman-Yassky, “Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches,” Journal of Allergy and Clinical Immunology, vol. 134, no. 4, pp. 769–779, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. M. Park, “Advances in the pathophysiology of atopic dermatitis,” Pediatric Allergy and Respiratory Disease, vol. 16, no. 3, pp. 189–196, 2006. View at Google Scholar
  8. H. Ogawa and T. Yoshiike, “A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis,” Journal of Dermatological Science, vol. 5, no. 3, pp. 197–204, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Asif, “Health effects of omega-3,6,9 fatty acids: perilla frutescens is a good example of plant oils,” Oriental Pharmacy & Experimental Medicine, vol. 11, no. 1, pp. 51–59, 2011. View at Publisher · View at Google Scholar
  10. J. S. Nam, “Studies on the nutritional components and physicochemical characteristics of various flax (Linum usitatissimum) seeds and oils,” The Korean Journal of Food and Nutrition, vol. 23, no. 4, pp. 516–525, 2010. View at Google Scholar
  11. http://www.drugs.com/npp/flax.html.
  12. A. Jung, S. Ahn, I. Park et al., “Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4,” BMC Complementary and Alternative Medicine, vol. 16, article e416, 2016. View at Publisher · View at Google Scholar
  13. E. Christophers and U. Mrowietz, “The inflammatory infiltrate in psoriasis,” Clinics in Dermatology, vol. 13, no. 2, pp. 131–135, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Okuda, T. Yoshiike, and H. Ogawa, “Detergent-induced epidermal barrier dysfunction and its prevention,” Journal of Dermatological Science, vol. 30, no. 3, pp. 173–179, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Y. M. Leung and T. Bieber, “Atopic dermatitis,” The Lancet, vol. 361, no. 9352, pp. 151–160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. P. M. Elias, M. L. Williams, M. E. Maloney et al., “Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis,” Journal of Clinical Investigation, vol. 74, no. 4, pp. 1414–1421, 1984. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Misery, “Skin, immunity and the nervous system,” British Journal of Dermatology, vol. 137, no. 6, pp. 843–850, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. P. S. Friedmann, B. B. Tan, E. Musaba, and I. Strickland, “Pathogenesis and management of atopic dermatitis,” Clinical and Experimental Allergy, vol. 25, no. 9, pp. 799–806, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. C. E. Lee, “Action mechanisms of cytokines/hormones utilizing JAK/STAT pathway,” Endocrinology and Metabolism, vol. 15, no. 3, pp. 367–387, 2000. View at Google Scholar
  20. P. A. Baeuerle and D. Baltimore, “Nf-κB: ten years after,” Cell, vol. 87, no. 1, pp. 13–20, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. P. A. Baeuerle, “IκB–NF-κB structures; at the interface of inflammation control,” Cell, vol. 95, no. 6, pp. 729–731, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Morise, S. Komatsu, J. W. Fuseler et al., “ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy,” American Journal of Physiology, vol. 274, no. 2, pp. G246–G252, 1998. View at Google Scholar · View at Scopus
  23. Y.-X. Li, N. Li, Y.-S. Li, B. Wu, and J.-S. Li, “Upregulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during rejection of rat small intestine allografts,” Transplantation Proceedings, vol. 32, no. 6, pp. 1283–1286, 2000. View at Publisher · View at Google Scholar · View at Scopus