Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice

Figure 2

Effects of electroacupuncture intervention at various acupoints on the spontaneous motor activity and methamphetamine- (METH-) induced behavioral sensitization. Mice were given saline or METH (2 mg/kg) intraperitoneally for 5 days. EA was applied from withdrawal days 3 to 5. The behavioral sensitization was induced using 1 mg/kg METH at withdrawal day 6. The bar graphs illustrate the cumulative distances of locomotor activity for a 1 h observation period. Spontaneous motor activity: (a) Zusanli (ST36)–Taichong (LR3), (b) Neiguan (PC6)–Quchi (LI11), and (c) Zhubin (KI9)–Taichong (LR3) and METH-induced behavioral sensitization: (d) ST36–LR3, (e) PC6–LI11, and (f) KI9–LR3. All data are expressed as means ± SEMs ( = 4–12 per group). < 0.01 and < 0.001 versus the Saline-Saline-Sham group; < 0.001 versus the Saline-METH-Sham group; < 0.01 versus METH-METH-Sham group (one-way ANOVA).

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