Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis

Figure 2

Body composition at the end of experiments. Ovariectomized (OVX) rats were provided with a 45% fat diet containing (1) 1% lyophilized DJY powder + MIA injection (DJY), (2) 1% lyophilized DJH powder + MIA injection (DJH), (3) 30 μg/kg body weight 17β-estradiol + 1% dextrose + MIA injection (positive control), (4) 1% dextrose + MIA injection (placebo, control), or (5) 1% dextrose with no MIA injection (normal control). After 4 weeks of the assigned diets, an articular injection of MIA into the right knee was made in all OVX groups except the normal-control group and the assigned diets were provided for an additional 3 weeks. At the 7th week body composition was measured by DEXA. (a) Bone mineral density (BMD). (b) Lean body mass (LBM) at the hip and right leg. (c) Fat mass (FM) at the abdomen and right leg. Each bar and error bar represents the mean ± SD from 10 rats per group. Different letters indicate significant differences in the treatment groups of OVX rats by Tukey’s test at .

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(b)

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