Investigating the Mechanisms of Action of Depside Salt from Salvia miltiorrhiza Using Bioinformatic Analysis

Table 3

Pathways enriched for the genes separately involved in module 1 and module 2 (top 10 listed).

Module	Term	Count	Genes	FDR
Module 1	hsa04668:TNF signaling pathway	12	PIK3CG, FOS, IL6, CCL2, MAP2K1, JUN, CREB1, NFKB1, MAPK8, BIRC3, IKBKB, BIRC2
	hsa05161:Hepatitis B	11	PIK3CG, FOS, IL6, MAP2K1, GRB2, JUN, BCL2, CREB1, NFKB1, MAPK8, IKBKB
	hsa04660:T cell receptor signaling pathway	10	PIK3CG, FOS, MAP2K1, GRB2, JUN, LCK, ZAP70, NFKB1, IKBKB, IL2
	hsa04380:Osteoclast differentiation	10	PIK3CG, FOS, MAP2K1, GRB2, JUN, CREB1, LCK, NFKB1, MAPK8, IKBKB
	hsa05200:Pathways in cancer	13	PIK3CG, FOS, IL6, XIAP, MAP2K1, GRB2, JUN, BCL2, NFKB1, MAPK8, BIRC3, IKBKB, BIRC2
	hsa05142:Chagas disease (American trypanosomiasis)	9	PIK3CG, FOS, IL6, CCL2, JUN, NFKB1, MAPK8, IKBKB, IL2
	hsa04722:Neurotrophin signaling pathway	9	PIK3CG, MAP2K1, GRB2, JUN, BCL2, NFKB1, MAPK8, SHC1, IKBKB
	hsa04510:Focal adhesion	10	PIK3CG, XIAP, MAP2K1, GRB2, JUN, BCL2, MAPK8, SHC1, BIRC3, BIRC2
	hsa04064:NF-kappa B signaling pathway	8	XIAP, BCL2, LCK, ZAP70, NFKB1, BIRC3, IKBKB, BIRC2
	hsa04621:NOD-like receptor signaling pathway	7	IL6, CCL2, NFKB1, MAPK8, BIRC3, IKBKB, BIRC2
Module 2	hsa05140:Leishmaniasis	7	IL4, TNF, PTGS2, RELA, IFNG, IL1B, NOS2
	hsa05142:Chagas disease (American trypanosomiasis)	7	CCL3, TNF, RELA, SERPINE1, IFNG, IL1B, NOS2
	hsa05146:Amoebiasis	6	CASP3, TNF, RELA, IFNG, IL1B, NOS2
	hsa05321:Inflammatory bowel disease (IBD)	5	IL4, TNF, RELA, IFNG, IL1B
	hsa05133:Pertussis	5	CASP3, TNF, RELA, IL1B, NOS2
	hsa05152:Tuberculosis	6	CASP3, TNF, RELA, IFNG, IL1B, NOS2
	hsa05132:Salmonella infection	5	CCL3, RELA, IFNG, IL1B, NOS2
	hsa04066:HIF-1 signaling pathway	5	RELA, SERPINE1, IFNG, NOS3, NOS2
	hsa04668:TNF signaling pathway	5	CASP3, TNF, PTGS2, RELA, IL1B
	hsa05145:Toxoplasmosis	5	CASP3, TNF, RELA, IFNG, NOS2