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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 5748256, 52 pages
https://doi.org/10.1155/2017/5748256
Review Article

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

1Laboratório de Tecnologia & Biotecnologia Farmacêutica (TecBioFar), Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil
2Grupo de Pesquisa em Produtos Naturais Bioativos (PNBio), Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil

Correspondence should be addressed to Matheus de Freitas Fernandes-Pedrosa

Received 23 February 2017; Accepted 9 July 2017; Published 21 August 2017

Academic Editor: Rainer W. Bussmann

Copyright © 2017 Juliana Félix-Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Gutiérrez, T. Burnouf, R. A. Harrison et al., “A call for incorporating social research in the global struggle against snakebite,” PLoS Neglected Tropical Diseases, vol. 9, no. 9, article e0003960, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Kasturiratne, A. R. Wickremasinghe, N. de Silva et al., “The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths,” PLoS Medicine, vol. 5, no. 11, article e218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. M. Gutiérrez, D. A. Warrell, D. J. Williams et al., “The need for full integration of snakebite envenoming within a global strategy to combat the neglected tropical diseases: the way forward,” PLoS Neglected Tropical Diseases, vol. 7, no. 6, Article ID e2162, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. R. A. Harrison, A. Hargreaves, S. C. Wagstaff, B. Faragher, and D. G. Lalloo, “Snake envenoming: a disease of poverty,” PLoS Neglected Tropical Diseases, vol. 3, no. 12, article e569, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. D. A. Warrell, “Venomous animals,” Medicine, vol. 40, no. 3, pp. 159–163, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. C. L. S. Guimarães, L. S. Moreira-Dill, R. S. Fernandes et al., “Biodiversity as a source of bioactive compounds against snakebites,” Current Medicinal Chemistry, vol. 21, no. 25, pp. 2952–2979, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. T. S. Kang, D. Georgieva, N. Genov et al., “Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis,” The FEBS Journal, vol. 278, no. 23, pp. 4544–4576, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. GutiΘrrez and B. Lomonte, “Local tissue damage induced by Bothrops snake venoms. A review,” Memorias do Instituto Butantan, vol. 51, no. 4, pp. 211–23, 1989. View at Google Scholar
  9. J. M. Gutiérrez, G. León, and T. Burnouf, “Antivenoms for the treatment of snakebite envenomings: the road ahead,” Biologicals, vol. 39, no. 3, pp. 129–142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. G. León, M. Herrera, Á. Segura, M. Villalta, M. Vargas, and J. M. Gutiérrez, “Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms,” Toxicon, vol. 76, pp. 63–76, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. W. B. Mors, M. C. do Nascimento, J. P. Parente, M. H. da Silva, P. A. Melo, and G. Suarez-Kurtz, “Neutralization of lethal and myotoxic activities of south american rattlesnake venom by extracts and constituents of the plant Eclipta prostrata (Asteraceae),” Toxicon, vol. 27, no. 9, pp. 1003–1009, 1989. View at Publisher · View at Google Scholar · View at Scopus
  12. M. S. Santhosh, M. Hemshekhar, K. Sunitha et al., “Snake venom induced local toxicities: plant secondary metabolites as an auxiliary therapy,” Mini-Reviews in Medicinal Chemistry, vol. 13, no. 1, pp. 106–123, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Shabbir, M. Shahzad, P. Masci, and G. C. Gobe, “Protective activity of medicinal plants and their isolated compounds against the toxic effects from the venom of Naja (cobra) species,” Journal of Ethnopharmacology, vol. 157, pp. 222–227, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Dey and J. N. de, “Phytopharmacology of antiophidian botanicals: A review,” International Journal of Pharmacology, vol. 8, no. 2, pp. 62–79, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Gomes, R. Das, S. Sarkhel et al., “Herbs and herbal constituents active against snake bite,” Indian Journal of Experimental Biology, vol. 48, no. 9, pp. 865–878, 2010. View at Google Scholar · View at Scopus
  16. A. Sulochana, D. Raveendran, A. Krishnamma, and O. Oommen, “Ethnomedicinal plants used for snake envenomation by folk traditional practitioners from Kallar forest region of South Western Ghats, Kerala, India,” Journal of Intercultural Ethnopharmacology, vol. 4, no. 1, p. 47, 2015. View at Publisher · View at Google Scholar
  17. M. A. Butt, M. Ahmad, A. Fatima et al., “Ethnomedicinal uses of plants for the treatment of snake and scorpion bite in Northern Pakistan,” Journal of Ethnopharmacology, vol. 168, pp. 164–181, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. R. M. Dharmadasa, G. C. Akalanka, P. R. M. Muthukumarana, and R. G. S. Wijesekara, “Ethnopharmacological survey on medicinal plants used in snakebite treatments in Western and Sabaragamuwa provinces in Sri Lanka,” Journal of Ethnopharmacology, vol. 179, pp. 110–127, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. C. P. Kala, “Herbal treatment for snakebites in Uttarakhand state of India,” Indian Journal of Natural Products and Resources, vol. 6, no. 1, pp. 56–61, 2015. View at Google Scholar · View at Scopus
  20. R. P. Samy, M. M. Thwin, P. Gopalakrishnakone, and S. Ignacimuthu, “Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India,” Journal of Ethnopharmacology, vol. 115, no. 2, pp. 302–312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Rajadurai, V. G. Vidhya, M. Ramya, and A. Bhaskar, “Ethno-medicinal plants used by the traditional healers of pachamalai hills, Tamilnadu, India,” Studies on Ethno-Medicine, vol. 3, no. 1, pp. 39–41, 2009. View at Google Scholar · View at Scopus
  22. S. Sarkhel, “Ethnobotanical survey of folklore plants used in treatment of snakebite in Paschim Medinipur district, West Bengal,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 5, pp. 416–420, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Penchalapratap, G. Sudarsanam, R. Pushpan, and G. P. Prasad, “Herbal remedies for snake bites in ethnic practices of Chittoor District, Andhra Pradesh,” Ancient Science of Life, vol. 29, no. 4, pp. 13–16, 2010. View at Google Scholar
  24. A. K. Singh, A. S. Raghubanshi, and J. S. Singh, “Medical ethnobotany of the tribals of Sonaghati of Sonbhadra district, Uttar Pradesh, India,” Journal of Ethnopharmacology, vol. 81, no. 1, pp. 31–41, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Kadel and A. K. Jain, “Folklore claims on snakebite among some tribal communities of Central India,” Indian Journal of Traditional Knowledge, vol. 7, no. 2, pp. 296–299, 2008. View at Google Scholar · View at Scopus
  26. K. Yesodharan and K. A. Sujana, “Ethnomedicinal knowledge among Malamalasar tribe of Parambikulam wildlife sanctuary,” Indian Journal of Traditional Knowledge, vol. 6, no. 3, pp. 481–85, 2007. View at Google Scholar
  27. F. G. Coe and G. J. Anderson, “Snakebite ethnopharmacopoeia of eastern Nicaragua,” Journal of Ethnopharmacology, vol. 96, no. 1-2, pp. 303–323, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Prabu and R. Kumuthakalavalli, “Folk remedies of medicinal plants for snake bites, scorpion stings and dog bites in Eastern Ghats of Kolli Hills, Tamil Nadu, India,” International Journal of Research in Ayurveda and Pharmacy, vol. 3, no. 5, pp. 696–700, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Sanz-Biset, J. Campos-de-la-Cruz, M. A. Epiquién-Rivera, and S. Cañigueral, “A first survey on the medicinal plants of the Chazuta valley (Peruvian Amazon),” Journal of Ethnopharmacology, vol. 122, no. 2, pp. 333–362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. M. N. Hasan, M. N. K. Azam, M. N. Ahmed, and A. Hirashima, “A randomized ethnomedicinal survey of snakebite treatment in southwestern parts of Bangladesh,” Journal of Traditional and Complementary Medicine, vol. 6, no. 4, pp. 337–342, 2015. View at Publisher · View at Google Scholar
  31. B. O. Owuor and D. P. Kisangau, “Kenyan medicinal plants used as antivenin: a comparison of plant usage,” Journal of Ethnobiology and Ethnomedicine, vol. 2, no. 1, article 7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. M. F. Kadir, J. R. Karmoker, M. R. Alam, S. R. Jahan, S. Mahbub, and M. M. K. Mia, “Ethnopharmacological survey of medicinal plants used by traditional healers and indigenous people in Chittagong Hill Tracts, Bangladesh, for the treatment of snakebite,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 871675, 23 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. V. M. De Moura, L. A. Freitas De Sousa, M. Cristina Dos-Santos et al., “Plants used to treat snakebites in Santarém, western Pará, Brazil: an assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom,” Journal of Ethnopharmacology, vol. 161, pp. 224–232, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Vásquez, J. C. Alarcón, S. L. Jiménez et al., “Main plants used in traditional medicine for the treatment of snake bites n the regions of the department of Antioquia, Colombia,” Journal of Ethnopharmacology, vol. 170, pp. 158–166, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Otero, R. Fonnegra, S. L. Jiménez et al., “Snakebites and ethnobotany in the northwest region of Colombia. Part I: traditional use of plants,” Journal of Ethnopharmacology, vol. 71, no. 3, pp. 493–504, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Rahmatullah, A. Hasan, W. Parvin et al., “Medicinal plants and formulations used by the Soren clan of the Santal tribe in Rajshahi District, Bangladesh for treatment of various ailments,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 9, no. 3, pp. 350–359, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Rigat, J. Vallès, U. Dambrosio, A. Gras, J. Iglésias, and T. Garnatje, “Plants with topical uses in the Ripollès district (Pyrenees, Catalonia, Iberian Peninsula): Ethnobotanical survey and pharmacological validation in the literature,” Journal of Ethnopharmacology, vol. 164, pp. 162–179, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Jain, S. S. Katewa, S. K. Sharma, P. Galav, and V. Jain, “Snakelore and indigenous snakebite remedies practiced by some tribals of Rajasthan,” Indian Journal of Traditional Knowledge, vol. 10, no. 2, pp. 258–268, 2011. View at Google Scholar · View at Scopus
  39. A. N. Shukla, S. Srinivastan, and A. K. S. Rawat, “An ethnobotanical study of medicinal plants of Rewa district, Madhya Pradesh,” Indian Journal of Traditional Knowledge, vol. 9, no. 1, pp. 191–202, 2010. View at Google Scholar · View at Scopus
  40. M. Panghal, V. Arya, S. Yadav, S. Kumar, and J. P. Yadav, “Indigenous knowledge of medicinal plants used by Saperas community of Khetawas, Jhajjar District, Haryana, India,” Journal of Ethnobiology and Ethnomedicine, vol. 6, article 4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. A. V. Khan, Q. U. Ahmed, M. W. Khan, and A. A. Khan, “Herbal cure for poisons and poisonous bites from Western Uttar Pradesh, India,” Asian Pacific Journal of Tropical Disease, vol. 4, no. 1, pp. S116–S120, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Sikdar and U. Dutta, “Traditional phytotherapy among the Nath people of Assam,” Studies on Ethno-Medicine, vol. 2, no. 1, pp. 39–45, 2008. View at Google Scholar
  43. M. A. Khan, S. A. Khan, M. A. Quresh et al., “Ethnobotany of some useful plants of poonch valley azad kashmir,” Journal of Medicinal Plant Research, vol. 5, no. 26, pp. 6140–6151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Vásquez, S. L. Jiménez, I. C. Gómez et al., “Snakebites and ethnobotany in the eastern region of Antioquia, Colombia—the traditional use of plants,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 449–455, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. B. Sivasankari, M. Anandharaj, and P. Gunasekaran, “An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India,” Journal of Ethnopharmacology, vol. 153, no. 2, pp. 408–423, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. D. Mebs, “Notes on the traditional use of plants to treat snake bite in northern Papua New Guinea,” Toxicon, vol. 38, no. 2, pp. 299–302, 2000. View at Publisher · View at Google Scholar · View at Scopus
  47. M. D. F. Agra, K. N. Silva, I. J. L. D. Basílio, P. F. De Freitas, and J. M. Barbosa-Filho, “Survey of medicinal plants used in the region Northeast of Brazil,” Brazilian Journal of Pharmacognosy, vol. 18, no. 3, pp. 472–508, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. R. A. Ritter, M. V. B. Monteiro, F. O. B. Monteiro et al., “Ethnoveterinary knowledge and practices at Colares island, Pará state, eastern Amazon, Brazil,” Journal of Ethnopharmacology, vol. 144, no. 2, pp. 346–352, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. K. S. Murthy, P. C. Sharma, and P. Kishore, “Tribal remedies for snakebite from Orissa,” Ancient Science of Life, vol. 6, no. 2, pp. 122-123, 1986. View at Google Scholar
  50. L. C. Di Stasi and C. A. Hiruma-Lima, Plantas medicinais na Amazônia e na Mata Atlântica, UNESP, São Paulo, Brazil, 2nd edition, 2002.
  51. A. Belayneh and N. F. Bussa, “Ethnomedicinal plants used to treat human ailments in the prehistoric place of Harla and Dengego valleys, eastern Ethiopia,” Journal of Ethnobiology and Ethnomedicine, vol. 10, article 18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Ayyanar and S. Ignacimuthu, “Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 851–864, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. F. Haq, H. Ahmad, and M. Alam, “Traditional uses of medicinal plants of Nandiar Khuwarr catchment (District Battagram), Pakistan,” Journal of Medicinal Plants Research, vol. 5, no. 1, pp. 39–48, 2011. View at Google Scholar · View at Scopus
  54. A. Cheikhyoussef, M. Shapi, K. Matengu, and H. M. Ashekele, “Ethnobotanical study of indigenous knowledge on medicinal plant use by traditional healers in Oshikoto region, Namibia,” Journal of Ethnobiology and Ethnomedicine, vol. 7, article 10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Jain, S. S. Katewa, P. K. Galav, and P. Sharma, “Medicinal plant diversity of Sitamata wildlife sanctuary, Rajasthan, India,” Journal of Ethnopharmacology, vol. 102, no. 2, pp. 143–157, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. H. C. Dutt, N. Bhagat, and S. Pandita, “Oral traditional knowledge on medicinal plants in jeopardy among Gaddi shepherds in hills of northwestern Himalaya, J&K, India,” Journal of Ethnopharmacology, vol. 168, pp. 337–348, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. G. Odonne, C. Valadeau, J. Alban-Castillo, D. Stien, M. Sauvain, and G. Bourdy, “Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon),” Journal of Ethnopharmacology, vol. 146, no. 1, pp. 127–153, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Jankovic, “Communication and shared information,” Philosophical Studies. An International Journal for Philosophy in the Analytic Tradition, vol. 169, no. 3, pp. 489–508, 2014. View at Publisher · View at Google Scholar · View at MathSciNet
  59. M. R. Hernandez, C. H. Avila-Bello, and J. E. Morales-Mavil, “Etnobotánica y ecología de plantas utilizadas por tres curanderos contra la mordedura de serpiente en la región de Acayucan, Veracruz, México,” Boletin de la Sociedad Botanica de Mexico, vol. 81, pp. 89–100, 2007. View at Google Scholar
  60. M. Rahmatullah, D. Ferdausi, M. A. H. Mollik, R. Jahan, M. H. Chowdhury, and W. M. Haque, “A survey of medicinal plants used by Kavirajes of Chalna area, Khulna district, Bangladesh,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 7, no. 2, pp. 91–97, 2010. View at Google Scholar · View at Scopus
  61. P. Giovannini, “Medicinal plants of the Achuar (Jivaro) of Amazonian Ecuador: ethnobotanical survey and comparison with other Amazonian pharmacopoeias,” Journal of Ethnopharmacology, vol. 164, pp. 78–88, 2015. View at Publisher · View at Google Scholar · View at Scopus
  62. P. Karuppaiya and H. S. Tsay, “Therapeutic values, chemical constituents and toxicity of Taiwanese Dysosma pleiantha: a review,” Toxicology Letters, vol. 236, no. 2, pp. 90–97, 2015. View at Publisher · View at Google Scholar · View at Scopus
  63. R. D. Kshirsagar and N. P. Singh, “Some less known ethnomedicinal uses from Mysore and Coorg districts, Karnataka state, India,” Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 231–238, 2001. View at Publisher · View at Google Scholar · View at Scopus
  64. U. P. De Albuquerque and L. D. H. C. Andrade, “Uso de recursos vegetais da caatinga: O caso do agreste do Estado de Pernambuco (Nordeste do Brasil),” Interciencia, vol. 27, no. 7, pp. 336–346, 2002. View at Google Scholar · View at Scopus
  65. A. Cheikhyoussef and W. Embashu, “Ethnobotanical knowledge on indigenous fruits in Ohangwena and Oshikoto regions in Northern Namibia,” Journal of Ethnobiology and Ethnomedicine, vol. 9, no. 1, article 34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. A. Shah, K. A. Bharati, J. Ahmad, and M. Sharma, “New ethnomedicinal claims from Gujjar and Bakerwals tribes of Rajouri and Poonch districts of Jammu and Kashmir, India,” Journal of Ethnopharmacology, vol. 166, pp. 119–128, 2015. View at Publisher · View at Google Scholar
  67. H. C. Ong and M. Nordiana, “Malay ethno-medico botany in Machang, Kelantan, Malaysia,” Fitoterapia, vol. 70, no. 5, pp. 502–513, 1999. View at Publisher · View at Google Scholar · View at Scopus
  68. R. Seebaluck, A. Gurib-Fakim, and F. Mahomoodally, “Medicinal plants from the genus Acalypha (Euphorbiaceae): a review of their ethnopharmacology and phytochemistry,” Journal of Ethnopharmacology, vol. 159, pp. 137–157, 2015. View at Publisher · View at Google Scholar · View at Scopus
  69. P. Sharma and U. Devi, “Ethnobotanical uses of biofencing plants in Himachal Pradesh, Northwest Himalaya,” Pakistan Journal of Biological Sciences, vol. 16, no. 24, pp. 1957–1963, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Coelho-Ferreira, “Medicinal knowledge and plant utilization in an Amazonian coastal community of Marudá, Pará State (Brazil),” Journal of Ethnopharmacology, vol. 126, no. 1, pp. 159–175, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. F. C. S. Oliveira, R. F. M. Barros, and J. M. Moita Neto, “Medicinal plants used in rural communities from Oeiras Municipality, in the semi-arid region of Piauí State (PI), Brazil,” Revista Brasileira de Plantas Medicinais, vol. 12, no. 3, pp. 282–301, 2010. View at Publisher · View at Google Scholar · View at Scopus
  72. C. G. Crepaldi, J. L. A. Campos, U. P. Albuquerque, and M. F. Sales, “Richness and ethnobotany of the family Euphorbiaceae in a tropical semiarid landscape of Northeastern Brazil,” South African Journal of Botany, vol. 102, pp. 157–165, 2016. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Murugesan, V. Balasubramaniam, and H. Arthi, “Ethno medical knowledge of plants used by Irula Tribes, Chengal Combai, the Nilgiris, Tamilnadu,” Ancient Science of Life, vol. 24, no. 4, pp. 179–82, 2005. View at Google Scholar
  74. B. N. Nsuala, G. Enslin, and A. Viljoen, ““Wild cannabis”: a review of the traditional use and phytochemistry of Leonotis leonurus,” Journal of Ethnopharmacology, vol. 174, pp. 520–539, 2015. View at Publisher · View at Google Scholar · View at Scopus
  75. M. K. Swamy and U. R. Sinniah, “A Comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.: an Aromatic Medicinal Plant of Industrial Importance,” Molecules, vol. 20, no. 5, pp. 8521–8547, 2015. View at Publisher · View at Google Scholar
  76. D. W. Gakuya, S. M. Itonga, J. M. Mbaria, J. K. Muthee, and J. K. Musau, “Ethnobotanical survey of biopesticides and other medicinal plants traditionally used in Meru central district of Kenya,” Journal of Ethnopharmacology, vol. 145, no. 2, pp. 547–553, 2013. View at Publisher · View at Google Scholar · View at Scopus
  77. T. K. Hazarika, Lalramchuana, and B. P. Nautiyal, “Studies on wild edible fruits of Mizoram, India used as ethno-medicine,” Genetic Resources and Crop Evolution, vol. 59, no. 8, pp. 1767–1776, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. C. A. Gallardo-Casas, G. Guevara-Balcázar, E. Morales-Ramos et al., “Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 18, no. 3, pp. 287–294, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. L. Xia, Q. Guo, P. Tu, and X. Chai, “The genus Casearia: a phytochemical and pharmacological overview,” Phytochemistry Reviews, pp. 1–37, 2014. View at Publisher · View at Google Scholar · View at Scopus
  80. M. Molander, C. H. Saslis-Lagoudakis, A. K. Jäger, and N. Rønsted, “Cross-cultural comparison of medicinal floras used against snakebites,” Journal of Ethnopharmacology, vol. 139, no. 3, pp. 863–872, 2012. View at Publisher · View at Google Scholar · View at Scopus
  81. J. Félix-Silva, R. B. Giordani, A. A. D. Silva-Jr, S. M. Zucolotto, and M. D. F. Fernandes-Pedrosa, “Jatropha gossypiifolia L. (Euphorbiaceae): a review of traditional uses, phytochemistry, pharmacology, and toxicology of this medicinal plant,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 369204, 32 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  82. M. Molander, L. Nielsen, S. Søgaard et al., “Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and South Africa,” Journal of Ethnopharmacology, vol. 157, pp. 171–180, 2014. View at Publisher · View at Google Scholar · View at Scopus
  83. N. Thangavel and J. K. Gupta, “Anti-inflammatory and anti-snake venom activity of Andrographis stenophylla leaf,” Asian Journal of Chemistry, vol. 19, no. 2, pp. 1307–1312, 2007. View at Google Scholar · View at Scopus
  84. M. H. H. B. Asad, M. T. Razi, Durr-e-Sabih et al., “Anti-venom potential of Pakistani medicinal plants: inhibition of anticoagulation activity of Naja naja karachiensis toxin,” Current Science, vol. 105, no. 10, pp. 1419–1424, 2013. View at Google Scholar · View at Scopus
  85. G. Sakthivel, A. Dey, K. Nongalleima et al., “In vitro and in vivo evaluation of polyherbal formulation against Russell's viper and cobra venom and screening of bioactive components by docking studies,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 781216, 12 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  86. P. Soni and S. H. Bodakhe, “Antivenom potential of ethanolic extract of Cordia macleodii bark against Naja venom,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, pp. S449–S454, 2014. View at Publisher · View at Google Scholar · View at Scopus
  87. M. A. Ibrahim, A. B. Aliyu, A. Abusufiyanu, M. Bashir, and A. B. Sallau, “Inhibition of naja nigricolis (Reinhardt) venom protease activity by Luffa egyptiaca (Mill) and Nicotiana rustica (Linn) extracts,” Indian Journal of Experimental Biology, vol. 49, no. 7, pp. 552–554, 2011. View at Google Scholar · View at Scopus
  88. K. Gopi, K. Renu, B. Sannanaik Vishwanath, and G. Jayaraman, “Protective effect of Euphorbia hirta and its components against snake venom induced lethality,” Journal of Ethnopharmacology, vol. 165, pp. 180–190, 2015. View at Publisher · View at Google Scholar · View at Scopus
  89. K. V. N. Rathnakar Reddi, S. S. Rajesh, K. Narendra et al., “In vitro anti-venom potential of various Jatropha extracts on neutralizing cytotoxic effect induced by phospholipase A2 of crude venom from Indian cobra (Naja naja),” Bangladesh Journal of Pharmacology, vol. 9, no. 1, pp. 22–28, 2014. View at Publisher · View at Google Scholar · View at Scopus
  90. M. Mahanta and A. K. Mukherjee, “Neutralisation of lethality, myotoxicity and toxic enzymes of Naja kaouthia venom by Mimosa pudica root extracts,” Journal of Ethnopharmacology, vol. 75, no. 1, pp. 55–60, 2001. View at Publisher · View at Google Scholar · View at Scopus
  91. K. S. Girish, H. P. Mohanakumari, S. Nagaraju, B. S. Vishwanath, and K. Kemparaju, “Hyaluronidase and protease activities from Indian snake venoms: Neutralization by Mimosa pudica root extract,” Fitoterapia, vol. 75, no. 3-4, pp. 378–380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  92. S. Meenatchisundaram, S. Priyagrace, R. Vijayaraghavan, A. Velmurugan, G. Parameswari, and A. Michael, “Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus venoms,” Bangladesh Journal of Pharmacology, vol. 4, no. 2, pp. 105–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  93. I. U. Asuzu and A. L. Harvey, “The antisnake venom activities of Parkia biglobosa (Mimosaceae) stem bark extract,” Toxicon, vol. 42, no. 7, pp. 763–768, 2003. View at Publisher · View at Google Scholar · View at Scopus
  94. K. Gopi, K. Renu, and G. Jayaraman, “Inhibition of Naja naja venom enzymes by the methanolic extract of Leucas aspera and its chemical profile by GC-MS,” Toxicology Reports, vol. 1, pp. 667–673, 2014. View at Publisher · View at Google Scholar · View at Scopus
  95. I. Chatterjee, A. K. Chakravarty, and A. Gomes, “Antisnake venom activity of ethanolic seed extract of Strychnos nux vomica Linn,” Indian Journal of Experimental Biology, vol. 42, no. 5, pp. 468–475, 2004. View at Google Scholar · View at Scopus
  96. J. Félix-Silva, T. Souza, Y. A. S. Menezes et al., “Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom,” PLoS ONE, vol. 9, no. 8, Article ID e104952, 2014. View at Publisher · View at Google Scholar · View at Scopus
  97. WHO, Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins, WHO Press, Geneva, Switzerland, 2010.
  98. V. Mourão De Moura, A. N. Serra Bezerra, R. H. Veras Mourão et al., “A comparison of the ability of Bellucia dichotoma Cogn. (Melastomataceae) extract to inhibit the local effects of Bothrops atrox venom when pre-incubated and when used according to traditional methods,” Toxicon, vol. 85, pp. 59–68, 2014. View at Publisher · View at Google Scholar · View at Scopus
  99. F. F. A. Fernandes, M. A. Tomaz, C. Z. El-Kik et al., “Counteraction of Bothrops snake venoms by Combretum leprosum root extract and arjunolic acid,” Journal of Ethnopharmacology, vol. 155, no. 1, pp. 552–562, 2014. View at Publisher · View at Google Scholar · View at Scopus
  100. E. C. De Oliveira, C. P. Fernandes, E. F. Sanchez, L. Rocha, and A. L. Fuly, “Inhibitory effect of plant Manilkara subsericea against biological activities of Lachesis muta snake venom,” BioMed Research International, vol. 2014, Article ID 408068, 2014. View at Publisher · View at Google Scholar · View at Scopus
  101. J. Saturnino-Oliveira, D. D. C. Santos, A. G. Guimarães et al., “Abarema cochliacarpos extract decreases the inflammatory process and skeletal muscle injury induced by bothrops leucurus venom,” BioMed Research International, vol. 2014, Article ID 820761, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  102. M. A. Strauch, M. A. Tomaz, M. Monteiro-Machado et al., “Antiophidic activity of the extract of the Amazon plant Humirianthera ampla and constituents,” Journal of Ethnopharmacology, vol. 145, no. 1, pp. 50–58, 2013. View at Publisher · View at Google Scholar · View at Scopus
  103. P. J. Houghton and I. M. Osibogun, “Flowering plants used against snakebite,” Journal of Ethnopharmacology, vol. 39, no. 1, pp. 1–29, 1993. View at Publisher · View at Google Scholar · View at Scopus
  104. P. A. Shenoy, S. S. Nipate, J. M. Sonpetkar, N. C. Salvi, A. B. Waghmare, and P. D. Chaudhari, “Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle,” Journal of Ethnopharmacology, vol. 147, no. 2, pp. 373–382, 2013. View at Publisher · View at Google Scholar · View at Scopus
  105. S. D. Araújo, A. de Souza, F. P. B. Nunes, and L. R. C. Gonçalves, “Effect of dexamethasone associated with serum therapy on treatment of Bothrops jararaca venom-induced paw edema in mice,” Inflammation Research, vol. 56, no. 10, pp. 409–413, 2007. View at Publisher · View at Google Scholar · View at Scopus
  106. F. C. Patrão-Neto, M. A. Tomaz, M. A. Strauch et al., “Dexamethasone antagonizes the in vivo myotoxic and inflammatory effects of Bothrops venoms,” Toxicon, vol. 69, pp. 55–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  107. I. Gómez-Betancur, D. Benjumea, A. Patiño, N. Jiménez, and E. Osorio, “Inhibition of the toxic effects of Bothrops asper venom by pinostrobin, a flavanone isolated from Renealmia alpinia (Rottb.) MAAS,” Journal of Ethnopharmacology, vol. 155, no. 3, pp. 1609–1615, 2014. View at Publisher · View at Google Scholar · View at Scopus
  108. A. Magalhães, G. B. D. Santos, M. C. D. S. Verdam et al., “Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys,” Journal of Ethnopharmacology, vol. 134, no. 1, pp. 82–88, 2011. View at Publisher · View at Google Scholar · View at Scopus
  109. I. C. Pereira, A. M. Barbosa, M. J. Salvador et al., “Anti-inflammatory activity of Blutaparon portulacoides ethanolic extract against the inflammatory reaction induced by Bothrops jararacussu venom and isolated myotoxins BthTX-I and II,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 15, no. 3, pp. 527–545, 2009. View at Publisher · View at Google Scholar · View at Scopus
  110. F. P. Reis, I. M. Senna Bonfa, R. B. Cavalcante et al., “Tabebuia aurea decreases inflammatory, myotoxic and hemorrhagic activities induced by the venom of Bothrops neuwiedi,” Journal of Ethnopharmacology, pp. 352–357, 2014. View at Publisher · View at Google Scholar · View at Scopus
  111. J. A. Pereañez, T. Lobo-Echeverri, B. Rojano et al., “Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts,” Brazilian Journal of Pharmacognosy, vol. 20, no. 6, pp. 910–916, 2010. View at Publisher · View at Google Scholar · View at Scopus
  112. K. Sunitha, M. Hemshekhar, R. M. Thushara et al., “Inflammation and oxidative stress in viper bite: an insight within and beyond,” Toxicon, vol. 98, pp. 89–97, 2015. View at Publisher · View at Google Scholar · View at Scopus
  113. P. Saravia-Otten, J. M. Gutiérrez, S. Arvidson, M. Thelestam, and J.-I. Flock, “Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage,” Journal of Infectious Diseases, vol. 196, no. 5, pp. 748–754, 2007. View at Publisher · View at Google Scholar · View at Scopus
  114. M. T. Jorge and L. A. Ribeiro, “Infections in the bite site after envenoming by snakes of the Bothrops genus,” Journal of Venomous Animals and Toxins, vol. 3, no. 2, pp. 264–272, 1997. View at Publisher · View at Google Scholar · View at Scopus
  115. T. P. D. Silva, V. M. D. Moura, M. C. S. D. Souza et al., “Connarus favosus Planch.: An inhibitor of the hemorrhagic activity of Bothrops atrox venom and a potential antioxidant and antibacterial agent,” Journal of Ethnopharmacology, vol. 183, pp. 166–175, 2016. View at Publisher · View at Google Scholar · View at Scopus
  116. R. Dehghani, M. R. Sharif, R. Moniri, A. Sharif, and H. H. Kashani, “The identification of bacterial flora in oral cavity of snakes,” Comparative Clinical Pathology, vol. 25, no. 2, pp. 279–283, 2016. View at Publisher · View at Google Scholar · View at Scopus
  117. P. Hearn, T. Miliya, S. Hor, V. Sar, and P. Turner, “Necrotizing fasciitis complicating snakebite in Cambodia,” IDCases, vol. 2, no. 3, article 70, pp. 86-87, 2015. View at Publisher · View at Google Scholar · View at Scopus
  118. D. S. Palappallil, “Pattern of use of antibiotics following snake bite in a tertiary care hospital,” Journal of Clinical and Diagnostic Research, vol. 9, no. 8, pp. OC05–OC09, 2015. View at Publisher · View at Google Scholar · View at Scopus
  119. J. Félix-Silva, J. A. Gomes, J. B. Xavier-Santos et al., “Inhibition of local effects induced by Bothrops erythromelas snake venom: assessment of the effectiveness of Brazilian polyvalent bothropic antivenom and aqueous leaf extract of Jatropha gossypiifolia,” Toxicon, vol. 125, pp. 74–83, 2017. View at Publisher · View at Google Scholar
  120. C. A. H. Fernandes, F. F. Cardoso, W. G. L. Cavalcante et al., “Structural basis for the inhibition of a phospholipase A2-like toxin by caffeic and aristolochic acids,” PLoS ONE, vol. 10, no. 7, Article ID e0133370, 2015. View at Publisher · View at Google Scholar · View at Scopus
  121. V. Srinivasa, M. S. Sundaram, S. Anusha et al., “Novel apigenin based small molecule that targets snake venom metalloproteases,” PLoS ONE, vol. 9, no. 9, Article ID e106364, 2014. View at Publisher · View at Google Scholar · View at Scopus
  122. J. A. Pereañez, A. C. Patiño, V. Núñez, and E. Osorio, “The biflavonoid morelloflavone inhibits the enzymatic and biological activities of a snake venom phospholipase A2,” Chemico-Biological Interactions, vol. 220, pp. 94–101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  123. M. Molander, D. Staerk, H. Mørck Nielsen et al., “Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites,” Journal of Ethnopharmacology, vol. 165, pp. 1–8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  124. R. Otero, V. Núñez, J. Barona et al., “Snakebites and ethnobotany in the northwest region of Colombia—Part III: Neutralization of the haemorrhagic effect of Bothrops atrox venom,” Journal of Ethnopharmacology, vol. 73, no. 1-2, pp. 233–241, 2000. View at Publisher · View at Google Scholar · View at Scopus
  125. R. Biondo, A. M. S. Pereira, S. Marcussi, P. S. Pereira, S. C. França, and A. M. Soares, “Inhibition of enzymatic and pharmacological activities of some snake venoms and toxins by Mandevilla velutina (Apocynaceae) aqueous extract,” Biochimie, vol. 85, no. 10, pp. 1017–1025, 2003. View at Publisher · View at Google Scholar · View at Scopus
  126. E. L. G. Veronese, L. E. Esmeraldino, A. P. F. Trombone et al., “Inhibition of the myotoxic activity of Bothrops jararacussu venom and its two major myotoxins, BthTX-I and BthTX-II, by the aqueous extract of Tabernaemontana catharinensis A. DC. (Apocynaceae),” Phytomedicine, vol. 12, no. 1-2, pp. 123–130, 2005. View at Publisher · View at Google Scholar · View at Scopus
  127. V. Núñez, R. Otero, J. Barona et al., “Neutralization of the edema-forming, defibrinating and coagulant effects of Bothrops asper venom by extracts of plants used by healers in Columbia,” Brazilian Journal of Medical and Biological Research, vol. 37, no. 7, pp. 969–977, 2004. View at Publisher · View at Google Scholar · View at Scopus
  128. V. M. de Moura, L. A. F. de Sousa, R. B. de Oliveira et al., “Inhibition of the principal enzymatic and biological effects of the crude venom of Bothrops atrox by plant extracts,” Journal of Medicinal Plants Research, vol. 7, no. 31, pp. 2330–2337, 2013. View at Publisher · View at Google Scholar
  129. B. Badilla, F. Chaves, G. Mora, and L. J. Poveda, “Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts,” Revista de Biologia Tropical, vol. 54, no. 2, pp. 245–252, 2006. View at Google Scholar · View at Scopus
  130. P. A. Melo, M. C. D. Nascimento, W. B. Mors, and G. Suarez-Kurtz, “Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents,” Toxicon, vol. 32, no. 5, pp. 595–603, 1994. View at Publisher · View at Google Scholar · View at Scopus
  131. V. B. Mourao, G. M. Giraldi, and L. M. G. Neves, “Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats,” Acta Cirurgica Brasileira, vol. 29, no. 1, pp. 30–37, 2014. View at Publisher · View at Google Scholar
  132. Y. P. Motta, M. Sakate, R. M. B. Nogueira et al., “Quantification of cytokines in serum and paw homogenate of experimental intoxication for venom of the Bothropoides jararaca in Wistar rats treated with antivenom and Mikania glomerata,” Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, vol. 66, no. 5, pp. 1413–1418, 2014. View at Publisher · View at Google Scholar · View at Scopus
  133. D. P. C. Oliveira, M. R. L. Borrás, L. C. D. L. Ferreira, and J. L. López-Lozano, “Atividade antiinflamatória do extrato aquoso de Arrabidaea chica (Humb. & Bonpl.) B. Verl. sobre o edema induzido por venenos de serpentes amazônicas,” Revista Brasileira de Farmacognosia, vol. 19, no. 2B, pp. 643–49, 2009. View at Google Scholar
  134. R. Otero, V. Núñez, S. L. Jiménez et al., “Snakebites and ethnobotany in the northwest region of Colombia. Part II: Neutralization of lethal and enzymatic effects of Bothrops atrox venom,” Journal of Ethnopharmacology, vol. 71, no. 3, pp. 505–511, 2000. View at Publisher · View at Google Scholar · View at Scopus
  135. F. K. Ticli, L. I. S. Hage, R. S. Cambraia et al., “Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): Antiserum action potentiation and molecular interaction,” Toxicon, vol. 46, no. 3, pp. 318–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  136. E. C. De Oliveira, M. C. Anholeti, T. F. Domingos et al., “Inhibitory effect of the plant Clusia fluminensis against biological activities of Bothrops jararaca snake venom,” Natural Product Communications, vol. 9, no. 1, pp. 21–25, 2014. View at Google Scholar · View at Scopus
  137. L. C. D. S. Picanço, J. A. H. M. Bittencourt, S. V. C. Henriques et al., “Pharmacological activity of Costus spicatus in experimental Bothrops atrox envenomation,” Pharmaceutical Biology, vol. 54, no. 10, pp. 2103–2110, 2016. View at Publisher · View at Google Scholar · View at Scopus
  138. J. M. Fernandes, J. Félix-Silva, L. M. Da Cunha et al., “Inhibitory effects of hydroethanolic leaf extracts of kalanchoe brasiliensis and kalanchoepinnata (crassulaceae) against local effects induced by bothropsjararaca snake venom,” PLoS ONE, vol. 11, no. 12, Article ID e0168658, 2016. View at Publisher · View at Google Scholar · View at Scopus
  139. C. M. Nishijima, C. M. Rodrigues, M. A. Silva, M. Lopes-Ferreira, W. Vilegas, and C. A. Hiruma-Lima, “Anti-hemorrhagic activity of four brazilian vegetable species against Bothrops jararaca venom,” Molecules, vol. 14, no. 3, pp. 1072–1080, 2009. View at Publisher · View at Google Scholar · View at Scopus
  140. L. E. Esmeraldino, A. M. Souza, and S. V. Sampaio, “Evaluation of the effect of aqueous extract of Croton urucurana Baillon (Euphorbiaceae) on the hemorrhagic activity induced by the venom of Bothrops jararaca, using new techniques to quantify hemorrhagic activity in rat skin,” Phytomedicine, vol. 12, no. 8, pp. 570–576, 2005. View at Publisher · View at Google Scholar · View at Scopus
  141. J. A. D. S. Gomes, J. Félix-Silva, J. Morais Fernandes et al., “Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom,” BioMed Research International, vol. 2016, Article ID 6101742, 13 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  142. V. L. Mack-Wen, L. B. Rico, J. C. Alarc, J. A. Perea, and J. C. Alarcón, “Inhibición in vitro del veneno de Bothrops asper con extractos etanólicos de Brownea ariza B. (Caesalpiniaceae),” Vitae, vol. 18, no. 1, pp. 43–48, 2011. View at Google Scholar
  143. M. Salazar, L. Chérigo, H. Acosta, R. Otero, and S. Martínez-Luis, “Evaluation of anti-Bothrops asper venom activity of ethanolic extract of Brownea rosademonte leaves,” Acta Pharmaceutica, vol. 64, no. 4, pp. 475–483, 2014. View at Publisher · View at Google Scholar · View at Scopus
  144. V. S. Nazato, L. Rubem-Mauro, N. A. G. Vieira et al., “In vitro antiophidian properties of Dipteryx alata Vogel bark extracts,” Molecules, vol. 15, no. 9, pp. 5956–5970, 2010. View at Publisher · View at Google Scholar · View at Scopus
  145. J. O. Da Silva, J. S. Coppede, V. C. Fernandes et al., “Antihemorrhagic, antinucleolytic and other antiophidian properties of the aqueous extract from Pentaclethra macroloba,” Journal of Ethnopharmacology, vol. 100, no. 1-2, pp. 145–152, 2005. View at Publisher · View at Google Scholar · View at Scopus
  146. L. H. F. Vale, M. M. Mendes, A. Hamaguchi, A. M. Soares, V. M. Rodrigues, and M. I. Homsi-Brandeburgo, “Neutralization of pharmacological and toxic activities of Bothrops snake venoms by Schizolobium parahyba (Fabaceae) aqueous extract and its fractions,” Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 1, pp. 104–107, 2008. View at Publisher · View at Google Scholar · View at Scopus
  147. M. M. Mendes, C. F. Oliveira, D. S. Lopes et al., “Anti-snake venom properties of Schizolobium parahyba (caesalpinoideae) aqueous leaves extract,” Phytotherapy Research, vol. 22, no. 7, pp. 859–866, 2008. View at Publisher · View at Google Scholar · View at Scopus
  148. J. A. Perea, S. L. Jimenez, J. C. Quintana, and J. A. Pereañez, “Inhibición de las actividades proteolítica, coagulante y hemolítica indirecta inducidas por el veneno de Bothrops asper por extractos etanólicos de tres especies de heliconias,” Vitae, vol. 15, no. 1, pp. 157–164, 2008. View at Google Scholar
  149. M. Assafim, E. C. Coriolano, and S. E. Benedito, “Hypericum brasiliense plant extract neutralizes some biological effects of Bothrops jararaca snake venom,” Journal of Venom Research, vol. 2, pp. 11–16, 2011. View at Google Scholar
  150. H. N. Costa, M. C. Santos, A. F. Alcântara, M. C. Silva, R. C. França, and D. Piló-Veloso, “Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae),” Química Nova, vol. 31, no. 4, pp. 744–750, 2008. View at Publisher · View at Google Scholar
  151. M. M. Mendes, S. A. P. B. Vieira, M. S. R. Gomes et al., “Triacontyl p-coumarate: an inhibitor of snake venom metalloproteinases,” Phytochemistry, vol. 86, pp. 72–82, 2013. View at Publisher · View at Google Scholar · View at Scopus
  152. V. M. de Moura, L. Y. de Souza, N. da Costa Guimarães et al., “The potential of aqueous extracts of Bellucia dichotoma Cogn. (Melastomataceae) to inhibit the biological activities of Bothrops atrox venom: A comparison of specimens collected in the states of Pará and Amazonas, Brazil,” Journal of Ethnopharmacology, vol. 196, pp. 168–177, 2017. View at Publisher · View at Google Scholar
  153. B. Badilla, F. Chaves, S. Jiménez, G. Rodríguez, and L. J. Poveda, “Effects of an extract of Cissampelos pareira on the hemorrhagic and proteolytic activities from Bothrops asper venom,” Pharmacognosy Magazine, vol. 4, no. 13, pp. 27–31, 2008. View at Google Scholar · View at Scopus
  154. J. A. H. M. Bittencourt, N. K. S. de Oliveira, M. S. Cabral et al., “Antiophidian activity of Brosimum guianense (AUBL) Huber,” American Journal of Pharmacology and Toxicology, vol. 9, no. 2, pp. 148–156, 2014. View at Publisher · View at Google Scholar · View at Scopus
  155. M. H. Borges, D. L. F. Alves, D. S. Raslan et al., “Neutralizing properties of Musa paradisiaca L. (Musaceae) juice on phospholipase A2, myotoxic, hemorrhagic and lethal activities of crotalidae venoms,” Journal of Ethnopharmacology, vol. 98, no. 1-2, pp. 21–29, 2005. View at Publisher · View at Google Scholar · View at Scopus
  156. L. A. F. Sousa, V. M. Moura, and J. D. A. Raposo, “The effect of the aqueous extract of Myrcia guianensis (AubL) DC and its fractions against the hemorrhagic activity of Bothrops jararaca venom,” Journal of Medicinal Plants Research, vol. 7, no. 42, pp. 3139–46, 2013. View at Google Scholar
  157. F. G. Freitas, T. A. Silva, and F. Oliveira, “Toxicidade aguda e propriedades antiofídicas do extrato aquoso de Casearia grandiflora (Flacourtiaceae): atividades fosfolipásica A2, miotóxica e letal de peçonhas de B. moojeni e B. neuwiedi,” Bioscience Journal, vol. 21, no. 2, pp. 95–103, 2005. View at Google Scholar
  158. M. Cintra-Francischinelli, M. G. Silva, N. Andréo-Filho et al., “Antibothropic action of casearia sylvestris Sw. (flacourtiaceae) extracts,” Phytotherapy Research, vol. 22, no. 6, pp. 784–790, 2008. View at Publisher · View at Google Scholar · View at Scopus
  159. M. H. Borges, A. M. Soares, V. M. Rodrigues et al., “Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae),” Toxicon, vol. 39, no. 12, pp. 1863–1869, 2001. View at Publisher · View at Google Scholar · View at Scopus
  160. S. L. Da Silva, A. K. Calgarotto, J. S. Chaar, and S. Marangoni, “Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA2 activity,” Toxicon, vol. 52, no. 6, pp. 655–666, 2008. View at Publisher · View at Google Scholar · View at Scopus
  161. M. L. Da Silva, S. Marcussi, R. S. Fernandes et al., “Anti-snake venom activities of extracts and fractions from callus cultures of Sapindus saponaria,” Pharmaceutical Biology, vol. 50, no. 3, pp. 366–375, 2012. View at Publisher · View at Google Scholar · View at Scopus
  162. R. S. Fernandes, T. R. Costa, S. Marcussi et al., “Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 17, no. 1, pp. 85–93, 2011. View at Publisher · View at Google Scholar · View at Scopus
  163. N. Tribuiani, A. M. da Silva, M. C. Ferraz et al., “Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom,” BMC Complementary and Alternative Medicine, vol. 14, article 48, 2014. View at Publisher · View at Google Scholar · View at Scopus
  164. M. M. Melo, M. Lúcia, and G. G. Habermehl, “Plant extracts for topic therapy of Bothrops alternatus envenomation,” Brazilian Journal of Pharmacognosy, vol. 17, no. 1, pp. 29–34, 2007. View at Publisher · View at Google Scholar · View at Scopus
  165. M. Fernández, W. F. Ortiz, J. A. Pereáñez, and D. Martínez, “Evaluación de las propiedades antiofídicas del extracto etanólico y fracciones obtenidas de Renealmia alpinia(Rottb) Mass (Zingiberaceae) cultivada in vitro,” Vitae, vol. 17, no. 1, pp. 75–82, 2010. View at Google Scholar
  166. A. C. Patiño, J. López, M. Aristizábal, J. C. Quintana, and D. Benjumea, “Evaluation of the inhibitory effect of extracts from leaves of renealmia alpinia rottb. maas(Zingiberaceae) on the venom of bothrops asper (mapaná),” Biomedica, vol. 32, no. 3, pp. 365–374, 2012. View at Publisher · View at Google Scholar · View at Scopus
  167. O. J. Ode and I. U. Asuzu, “The anti-snake venom activities of the methanolic extract of the bulb of Crinum jagus (Amaryllidaceae),” Toxicon, vol. 48, no. 3, pp. 331–342, 2006. View at Publisher · View at Google Scholar · View at Scopus
  168. J. M. Gutiérrez, A. Rucavado, F. Chaves, C. Díaz, and T. Escalante, “Experimental pathology of local tissue damage induced by Bothrops asper snake venom,” Toxicon, vol. 54, no. 7, pp. 958–975, 2009. View at Publisher · View at Google Scholar · View at Scopus
  169. D. Paixão-Cavalcante, A. K. Kuniyoshi, F. C. V. Portaro, W. D. da Silva, and D. V. Tambourgi, “African Adders: Partial Characterization of Snake Venoms from Three Bitis Species of Medical Importance and Their Neutralization by Experimental Equine Antivenoms,” PLoS Neglected Tropical Diseases, vol. 9, no. 2, Article ID e0003419, 2015. View at Publisher · View at Google Scholar · View at Scopus
  170. S. Ushanandini, S. Nagaraju, S. C. Nayaka, K. H. Kumar, K. Kemparaju, and K. S. Girish, “The anti-ophidian properties of Anacardium occidentale bark extract,” Immunopharmacology and Immunotoxicology, vol. 31, no. 4, pp. 607–615, 2009. View at Publisher · View at Google Scholar · View at Scopus
  171. B. L. Dhananjaya, F. Zameer, K. S. Girish, and C. J. M. D'Souza, “Anti-venom potential of aqueous extract of stem bark of Mangifera indica L. against Daboia russellii (Russell's viper) venom,” Indian Journal of Biochemistry and Biophysics, vol. 48, no. 3, pp. 175–183, 2011. View at Google Scholar · View at Scopus
  172. M. I. Alam, B. Auddy, and A. Gomes, “Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus and Pluchea indica) root extracts,” Phytotherapy Research, vol. 10, no. 1, pp. 58–61, 1996. View at Publisher · View at Google Scholar · View at Scopus
  173. P. Bhattacharjee and D. Bhattacharyya, “Characterization of the aqueous extract of the root of Aristolochia indica: evaluation of its traditional use as an antidote for snake bites,” Journal of Ethnopharmacology, vol. 145, no. 1, pp. 220–226, 2013. View at Publisher · View at Google Scholar · View at Scopus
  174. A. Shirwaikar, K. Rajendran, R. Bodla, and C. D. Kumar, “Neutralization potential of Viper russelli russelli (Russell's viper) venom by ethanol leaf extract of Acalypha indica,” Journal of Ethnopharmacology, vol. 94, no. 2-3, pp. 267–273, 2004. View at Publisher · View at Google Scholar · View at Scopus
  175. S. Tarannum, R. Mohamed, and B. S. Vishwanath, “Inhibition of testicular and Vipera russelli snake venom hyaluronidase activity by Butea monosperma (Lam) Kuntze stem bark,” Natural Product Research, vol. 26, no. 18, pp. 1708–1711, 2012. View at Publisher · View at Google Scholar · View at Scopus
  176. K. M. Maung and Z. Lynn, “Effects of Tamarind (Tamarindus indicus Linn) seed extract on Russell's viper (Daboia russelli siamensis) venom,” Tropical Biomedicine, vol. 29, no. 4, pp. 580–587, 2012. View at Google Scholar · View at Scopus
  177. S. Ushanandini, S. Nagaraju, K. H. Kumar et al., “The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract,” Phytotherapy Research, vol. 20, no. 10, pp. 851–858, 2006. View at Publisher · View at Google Scholar · View at Scopus
  178. M. I. Alam and A. Gomes, “Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts,” Journal of Ethnopharmacology, vol. 86, no. 1, pp. 75–80, 2003. View at Publisher · View at Google Scholar · View at Scopus
  179. K. T. Chandrashekara, S. Nagaraju, S. Usha Nandini, Basavaiah, and K. Kemparaju, “Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract,” Phytotherapy Research, vol. 23, no. 8, pp. 1082–1087, 2009. View at Publisher · View at Google Scholar · View at Scopus
  180. S. A. Krishnan, R. Dileepkumar, A. S. Nair, and O. V. Oommen, “Studies on neutralizing effect of Ophiorrhiza mungos root extract against Daboia russelii venom,” Journal of Ethnopharmacology, vol. 151, no. 1, pp. 543–547, 2014. View at Publisher · View at Google Scholar · View at Scopus
  181. B. Janardhan, V. M. Shrikanth, K. K. Mirajkar, and S. S. More, “In vitro screening and evaluation of antivenom phytochemicals from Azima tetracantha Lam. leaves against bungarus caeruleus and Vipera russelli,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 20, no. 1, article 12, 2014. View at Publisher · View at Google Scholar · View at Scopus
  182. Y. H. Mahadeswaraswamy, S. Devaraja, M. S. Kumar, Y. N. J. Goutham, and K. Kemparaju, “Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds,” Indian Journal of Biochemistry and Biophysics, vol. 46, no. 2, pp. 154–160, 2009. View at Google Scholar · View at Scopus
  183. A. K. Mukherjee, B. Kalita, and S. P. Mackessy, “A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom,” Journal of Proteomics, vol. 144, pp. 73–86, 2016. View at Publisher · View at Google Scholar · View at Scopus
  184. W. Wüster, “The genus Daboia (Serpentes: Viperidae): Russell's viper,” Hamadryad, vol. 23, no. 1, pp. 33–40, 1998. View at Google Scholar
  185. D. A. Warrell, “Snake bite,” The Lancet, vol. 375, no. 9708, pp. 77–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  186. D. Pla, L. Sanz, P. Molina-Sánchez et al., “Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis,” Journal of Proteomics, vol. 89, pp. 112–123, 2013. View at Publisher · View at Google Scholar · View at Scopus
  187. J. M. Gutiérrez, “Comprendiendo los venenos de serpientes: 50 Años de investigaciones en América Latina,” Revista de Biologia Tropical, vol. 50, no. 2, pp. 377–394, 2002. View at Google Scholar · View at Scopus
  188. R. C. de Paula, E. F. Sanchez, T. R. Costa et al., “Antiophidian properties of plant extracts against Lachesis muta venom,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 16, no. 2, pp. 311–323, 2010. View at Google Scholar · View at Scopus
  189. E. C. De Oliveira, R. A. S. Cruz, N. D. M. Amorim et al., “Protective effect of the plant extracts of erythroxylum sp. against toxic effects induced by the venom of lachesis muta snake,” Molecules, vol. 21, no. 10, article 1350, 2016. View at Publisher · View at Google Scholar · View at Scopus
  190. R. Biondo, A. M. Soares, B. W. Bertoni, S. C. França, and A. M. S. Pereira, “Direct organogenesis of Mandevilla illustris (Vell) Woodson and effects of its aqueous extract on the enzymatic and toxic activities of Crotalus durissus terrificus snake venom,” Plant Cell Reports, vol. 22, no. 8, pp. 549–552, 2004. View at Publisher · View at Google Scholar · View at Scopus
  191. O. J. Ode, C. O. Nwaehujor, and M. M. Onakpa, “Evaluation of antihaemorrhagic and antioxidant potentials of Crinum jagus bulb,” International Journal of Applied Biology and Pharmaceutical Technology, vol. 1, no. 3, pp. 1330–1336, 2010. View at Google Scholar
  192. A. Nalbantsoy, Ş. B. Erel, Ç. Köksal, B. Göçmen, M. Z. Yildiz, and N. Ü. Karabay Yavaşoĝlu, “Viper venom induced inflammation with Montivipera xanthina (Gray, 1849) and the anti-snake venom activities of Artemisia absinthium L. in rat,” Toxicon, vol. 65, pp. 34–40, 2013. View at Publisher · View at Google Scholar · View at Scopus
  193. R. D. C. O. Collaço, J. C. Cogo, L. Rodrigues-Simioni, T. Rocha, Y. Oshima-Franco, and P. Randazzo-Moura, “Protection by Mikania laevigata (guaco) extract against the toxicity of Philodryas olfersii snake venom,” Toxicon, vol. 60, no. 4, pp. 614–622, 2012. View at Publisher · View at Google Scholar · View at Scopus
  194. P. U. Amog, V. N. Manjuprasanna, M. Yariswamy et al., “Albizia lebbeck seed methanolic extract as a complementary therapy to manage local toxicity of Echis carinatus venom in a murine model,” Pharmaceutical Biology, vol. 54, no. 11, pp. 2568–2574, 2016. View at Publisher · View at Google Scholar · View at Scopus
  195. A. N. Nanjaraj Urs, M. Yariswamy, V. Joshi et al., “Local and systemic toxicity of Echis carinatus venom: Neutralization by Cassia auriculata L. leaf methanol extract,” Journal of Natural Medicines, vol. 69, no. 1, pp. 111–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  196. S. S. Hasson, M. S. Al-Balushi, E. A. Said et al., “Neutralisation of local haemorrhage induced by the saw-scaled viper Echis carinatus sochureki venom using ethanolic extract of Hibiscus aethiopicus L,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 540671, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  197. S. S. Hasson, A. A. Al-Jabri, T. A. Sallam, M. S. Al-Balushi, and R. A. A. Mothana, “Antisnake venom activity of hibiscus aethiopicus L. against echis ocellatus and naja n. nigricollis,” Journal of Toxicology, vol. 2010, Article ID 837864, 2010. View at Publisher · View at Google Scholar · View at Scopus
  198. Y. H. Mahadeswaraswamy, S. Nagaraju, K. S. Girish, and K. Kemparaju, “Local tissue destruction and procoagulation properties of Echis carinatus venom: Inhibition by Vitis vinifera seed methanol extract,” Phytotherapy Research, vol. 22, no. 7, pp. 963–969, 2008. View at Publisher · View at Google Scholar · View at Scopus
  199. J. Boldrini-França, C. Corrêa-Netto, M. M. S. Silva et al., “Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: Assessment of geographic variation and its implication on snakebite management,” Journal of Proteomics, vol. 73, no. 9, pp. 1758–1776, 2010. View at Publisher · View at Google Scholar · View at Scopus
  200. M. L. Santoro, M. C. C. Sousa-E-Silva, L. R. C. Gonçalves et al., “Comparison of the biological activities in venoms from three subspecies of the South American rattlesnake (Crotalus durissus terrificus, C. durissus cascavella and C. durissus collilineatus),” Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, vol. 122, no. 1, pp. 61–73, 1999. View at Publisher · View at Google Scholar · View at Scopus
  201. F. Sangiorgio, M. Sakate, R. M. B. Nogueira, J. P. Araújo Jr., and C. Chavez-Olortegui, “Kinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom,” Journal of Venomous Animals and Toxins Including Tropical Diseases, vol. 14, no. 1, pp. 100–112, 2008. View at Google Scholar · View at Scopus
  202. V. Hiremath, A. N. Nanjaraj Urs, V. Joshi et al., “Differential action of medically important Indian BIG FOUR snake venoms on rodent blood coagulation,” Toxicon, vol. 110, pp. 19–26, 2016. View at Publisher · View at Google Scholar · View at Scopus
  203. Q. Chen, W. Wang, Q. Li, Y. Bai, X. Zou, and Y. Wu, “Effect of externally applied Jidesheng anti-venom on skin and soft-tissue necrosis after Chinese cobra bite: a retrospective study,” Journal of Traditional Chinese Medicine, vol. 34, no. 2, pp. 150–154, 2014. View at Publisher · View at Google Scholar · View at Scopus