Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells

Figure 9

Expression of LC3II and mTOR protein in PCa cells, detected by Western blot assay. (a) PANC-1 cells were treated with curcumin of different concentration. The protein expression of LC3II was significantly increased in 40 and 80 μg/ml groups, while mTOR protein expression was decreased in 20, 40, and 80 μg/ml group. (b) The protein expression of LC3II was significantly increased in 5 and 10 μg/ml groups of BxPC3 cells, while mTOR protein expression was decreased in 10 μg/ml group. Error bar, SEM. , significantly different with control group ().

(a)

(b)