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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 5820405, 8 pages
Research Article

Bletilla striata Micron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation

1The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base Co-Founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2College of Pharmacy, Southwest University for Nationalities, Chengdu 610041, China
3State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China

Correspondence should be addressed to Hanshuo Yang and Yan Qu

Received 20 December 2016; Accepted 21 February 2017; Published 12 March 2017

Academic Editor: Ipek Suntar

Copyright © 2017 Chen Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The human body cannot control blood loss without treatment. Available hemostatic agents are ineffective at treating cases of severe bleeding and are expensive or raise safety concerns. Bletilla striata serve as an inexpensive, natural, and promising alternative. However, no detailed studies on its hemostatic approach have been performed. The aim of this study was to examine the hemostatic effects of B. striata Micron Particles (BSMPs) and their hemostatic mechanisms. We prepared and characterized BSMPs of different size ranges and investigated their use as hemostatic agent. BSMPs of different size ranges were characterized by scanning electron microscope. In vitro coagulation studies revealed BSMP-blood aggregate formation via stereoscope and texture analyzers. In vivo studies based on rat injury model illustrated the BSMP capabilities under conditions of hemostasis. Compared to other BSMPs of different size ranges, BSMPs of 350–250 μm are most efficient in hemostasis. As powder sizes decrease, the degree of aggregation between particles and hemostatic BSMP effects declines. The BSMP in contact with a bleeding surface locally forms a visible particle/blood aggregate as a physical barrier that facilitates hemostasis. Considering the facile preparation, low cost, and long shelf life of B. striata, BSMPs offer great potential as mechanisms of trauma treatment.