The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis

Table 1

Clinical and demographic characteristics of the patients with gouty arthritis.

Study (ref.)	Number of participants		Age (years)		Intervention			Outcomes
	Experimental	Control	Experimental	Control	Experimental	Control	Duration (days)
Chen 2011 [12]	44	44	48.5 ± 9.26	49.01 ± 8.95	MSD	Colchicine; allopurinol	14	SUA; ESR; AEs
Fan and Weng 2016 [13]	30	30	48.0 ± 3.8	46.0 ± 3.6	MSD	Meloxicam	28	SUA; ESR; CRP; AEs
Fang 2008 [14]	20	20	57.35 ± 14.54	53.05 ± 14.47	MSD	Loxoprofen sodium	5	SUA; ESR; AEs
Gao et al. 2014 [15]	35	35	44.2 ± 7.2	39.4 ± 8.1	MSD	Colchicine; Etocoxib	7	SUA; ESR; CRP; AEs
Jia 2010 [16]	28	26	43.0 ± 10.8	44.0 ± 11.3	MSD	Colchicine	14	SUA; AEs
Li and Zhang 2007 [17]	40	40	47.5 ± 3.17	46.8 ± 2.74	MSD	Allopurinol	14	SUA
Li and Song 2013 [18]	35	35	NR	NR	MSD	Diclofenac sodium	7	SUA; AEs
Liu 2011 [19]	30	30	NR	NR	MSD	Allopurinol; nimesulide	21	SUA; ESR; CRP; WBC
Luo and Tang 2010 [20]	30	30	NR	NR	MSD	Colchicine; diclofenac sodium	3	SUA
Mi 2016 [21]	44	42	46.12 ± 8.21	45.42 ± 7.85	MSD	Allopurinol; nimesulide	21	SUA; ESR; CRP
Niu 2008 [22]	52	47	NR	NR	MSD	Colchicine	7	SUA
Renbin et al. 2008 [7]	60	60	46.9 ± 3.37	46.8 ± 3.24	MSD	Allopurinol	30	SUA; CRP
Shi et al. 2008 [6]	28	25	54.0 ± 12.5	52.9 ± 13.2	MSD	Indomethacin; benzbromarone	14	SUA; WBC; AEs
Sun 2006 [23]	36	28	53.2 ± 7.8	54.0 ± 8.3	MSD	Benzbromarone	28	SUA; ESR
Tang et al. 2008 [24]	30	26	NR	NR	MSD	Colchicine	15	SUA; AEs
Wang et al. 2009 [25]	90	88	NR	NR	MSD	Colchicine; benzbromarone	14	SUA; ESR; WBC; AEs
Wang et al. 2016 [26]	30	30	36.1 ± 2.8	36.7 ± 2.5	MSD	Colchicine	14	SUA; ESR; CRP
Wang et al. 2016 [27]	32	32	NR	NR	MSD	Allopurinol; NSAIDs	10	SUA; ESR; CRP; WBC; AEs
Yu and Huang 2008 [28]	40	40	48.2 ± 8.6	46.0 ± 9.7	MSD	Nimesulide; allopurinol	14	SUA; AEs
Zeng and Song 2013 [29]	60	58	NR	NR	MSD	Colchicine; allopurinol	14	SUA
Zhang and Chen 2012 [30]	36	28	45.2 ± 7.8	43.4 ± 8.3	MSD	Colchicine; allopurinol; Voltaren or celecoxib	7	SUA; ESR; WBC; AEs
Zhao and Mai 2008 [31]	41	40	NR	NR	MSD	Colchicine; allopurinol	30	SUA; ESR; WBC; AEs
Zhao 2014 [32]	48	45	NR	NR	MSD	Colchicine; allopurinol; Voltaren	7	SUA; ESR
Zhu 2016 [33]	49	48	45.77 ± 7.08	45.45 ± 7.18	MSD	Colchicine	15	SUA

Note: MSD: modified Simiao decoction; SUA: serum uric acid; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; WBC: white blood cell; AEs: adverse effects; NR, no report. Values are mean ± standard deviation (SD).