Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 6091923, 12 pages
https://doi.org/10.1155/2017/6091923
Research Article

Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway

1Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Republic of Korea
2Food and Bio-Industry Research Institute, Kyungpook National University, Daegu 41566, Republic of Korea
3Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202-9037, USA
4MR Innovation Co., Ltd., Technopark, Kyungpook National University, Daegu 41566, Republic of Korea

Correspondence should be addressed to Sang-Han Lee; rk.ca.unk@gnas

Received 20 March 2017; Accepted 24 April 2017; Published 18 May 2017

Academic Editor: Víctor López

Copyright © 2017 Peijun Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Abu-Farha, P. Cherian, I. Al-Khairi et al., “DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression,” Scientific Reports, vol. 5, p. 14448, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. International Diabetes Federation (IDF), Diabetes Atlas, 6th edition, 2014, http://www.idf.org/diabetesatlas/update-2014.
  3. B. Ma, J. Tong, G. Zhou, Q. Mo, J. He, and Y. Wang, “Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice,” Journal of Functional Foods, vol. 21, pp. 455–462, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Thiyagarajan and P. Venkatachalam, “A reproducible and high frequency plant regeneration from mature axillary node explants of Gymnema sylvestre (Gurmur)-An important antidiabetic endangered medicinal plant,” Industrial Crops and Products, vol. 50, pp. 517–524, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. H.-Y. Hung, K. Qian, S. L. Morris-Natschke, C.-S. Hsu, and K.-H. Lee, “Recent discovery of plant-derived anti-diabetic natural products,” Natural Product Reports, vol. 29, no. 5, pp. 580–606, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Pinent, A. Castell, I. Baiges, G. Montagut, L. Arola, and A. Ardévol, “Bioactivity of flavonoids on insulin-secreting cells,” Comprehensive Reviews in Food Science and Food Safety, vol. 7, no. 4, p. 299308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Huang and M. P. Czech, “The GLUT4 Glucose Transporter,” Cell Metabolism, vol. 5, no. 4, pp. 237–252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. D. G. Hardie, “Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism,” Proceedings of the Nutrition Society, vol. 70, no. 1, pp. 92–99, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Kang, H. Lee, E.-S. Jung et al., “Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms,” Food Chemistry, vol. 135, no. 4, pp. 2350–2358, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Monnier, E. Mas, C. Ginet et al., “Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes,” The Journal of the American Medical Association, vol. 295, no. 14, pp. 1681–1687, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Brownlee, “Biochemistry and molecular cell biology of diabetic complications,” Nature, vol. 414, no. 6865, pp. 813–820, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. R.C. Turner, R. R. Holman, I.M. Stratton et al., “Effect of intensive blood glucose control with metformin on complications in overweight pathients with type 2 diabetes (UKPDS 34),” The Lancet, vol. 352, pp. 854–865, 1998. View at Google Scholar
  13. M. Hotta, E. Yamato, and J. I. Miyazaki, “Oxidative stress and pancreatic β-cell destruction in insulin-dependent diabetes mellitus,” in Antioxidants and diabetes management, L. Packer, P. Rosen, H. Tritschler, G. L. King, and., and A. Azzi, Eds., pp. 265–274, Marcel Dekker, New York, USA, 2000. View at Google Scholar
  14. H. Kaneto, G. Xu, K.-H. Song et al., “Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress,” Journal of Biological Chemistry, vol. 276, no. 33, pp. 31099–31104, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Lee, Y. Lin, F. Hsu, G. Zhan, and K. Yen, “Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells,” Phytochemistry, vol. 67, no. 12, pp. 1262–1270, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Huang, L. Chen, L. Feng, F. Guo, and Y. Li, “Characterization of total phenolic constituents from the stems of Spatholobus suberectus using LC-DAD-MSn and their inhibitory effect on human neutrophil elastase activity,” Molecules, vol. 18, no. 7, pp. 7549–7556, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Chen, A. Wang, L. Lin, H. Qiu, Y. Wang, and Y. Wang, “In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn,” Molecules, vol. 21, p. 1367, 2016. View at Publisher · View at Google Scholar
  18. B.-J. Lee, I.-Y. Jo, Y. Bu et al., “Antiplatelet effects of Spatholobus suberectus via inhibition of the glycoprotein IIb/IIIa receptor,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 460–467, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. S. Ravipati, L. Zhang, S. R. Koyyalamudi et al., “Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content,” BMC Complementary and Alternative Medicine, vol. 12, p. 173, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Liao, L. K. Banbury, and D. N. Leach, “Antioxidant activity of 45 Chinese herbs and the relationship with their TCM characteristics,” Evidence-based Complementary and Alternative Medicine, vol. 5, no. 4, pp. 429–434, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. H. G. Soe, M. S. Oh, and D. H. Kim, “Immunity responses of the Spatholobussuberectus Dunn to synovial cells isolated from patients with rheumatoid arthritis,” Korean Journal of Oriental Physiology Pathology, vol. 17, pp. 780–786, 2003. View at Google Scholar
  22. Z.-Y. Wang, D.-M. Wang, T. Y. Loo et al., “Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 751–758, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Kumar, P. Bhandari, B. Singh, A. P. Gupta, and V. K. Kaul, “Reversed phase-HPLC for rapid determination of polyphenols in flowers of rose species,” Journal of Separation Science, vol. 31, no. 2, pp. 262–267, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Nanjo, K. Goto, R. Seto, M. Suzuki, M. Sakai, and Y. Hara, “Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical,” Free Radical Biology and Medicine, vol. 21, pp. 895–902, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, and C. Rice-Evans, “Antioxidant activity applying an improved ABTS radical cation decolorization assay,” Free Radical Biology & Medicine, vol. 26, pp. 1231–1237, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Apak, K. Güçlü, M. Özyürek, and S. E. Karademir, “Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method,” Journal of Agricultural and Food Chemistry, vol. 52, pp. 7970–7981, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. M. S. Kim, H. J. Hur, D. Y. Kwon, and J.-T. Hwang, “Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice,” Molecular and Cellular Endocrinology, vol. 358, no. 1, pp. 127–134, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Pandeti, D. Arha, A. Mishra et al., “Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis,” European Journal of Pharmacology, vol. 789, pp. 449–457, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. I. C. West, “Radicals and oxidative stress in diabetes,” Diabetic Medicine, vol. 17, no. 3, pp. 171–180, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Gastaldelli, Y. Miyazaki, M. Pettiti et al., “The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 3, pp. 806–812, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Barthel and D. Schmoll, “Novel concepts in insulin regulation of hepatic gluconeogenesis,” American Journal of Physiology - Endocrinology and Metabolism, vol. 285, no. 4, pp. E685–E692, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. F. E. Koehn and G. T. Carter, “The evolving role of natural products in drug discovery,” Nature Reviews Drug Discovery, vol. 4, no. 3, pp. 206–220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. D. B. Savage, K. F. Petersen, and G. I. Shulman, “Disordered lipid metabolism and the pathogenesis of insulin resistance,” Physiological Reviews, vol. 87, no. 2, pp. 507–520, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Zorzano, C. Fandos, and M. Palacín, “Role of plasma membrane transporters in muscle metabolism,” Biochemical Journal, vol. 349, no. 3, pp. 667–688, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Chang, S. H. Chiang, and A. R. Saltiel, “Insulin signaling and the regulation of glucose transport,” Molecular Medicine, vol. 10, pp. 64–71, 2004. View at Google Scholar
  37. R. T. Watson, M. Kanzaki, and J. E. Pessin, “Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes,” Endocrine Reviews, vol. 25, no. 2, pp. 177–204, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. D. G. Hardie, “AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease,” Journal of Internal Medicine, vol. 276, no. 6, pp. 543–559, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. L.-Z. Liu, S. C. K. Cheung, L.-L. Lan et al., “Berberine modulates insulin signaling transduction in insulin-resistant cells,” Molecular and Cellular Endocrinology, vol. 317, no. 1-2, pp. 148–153, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Ueda, T. Furuyashiki, K. Yamada et al., “Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes,” Food and Function, vol. 1, no. 2, pp. 167–173, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Murase, K. Misawa, S. Haramizu, and T. Hase, “Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway,” Biochemical Pharmacology, vol. 78, no. 1, pp. 78–84, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. Q. Luo, Y. Cai, J. Yan, M. Sun, and H. Corke, “Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum,” Life Sciences, vol. 76, no. 2, pp. 137–149, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. J. L. Evans, I. D. Goldfine, B. A. Maddux, and G. M. Grodsky, “Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes,” Endocrine Reviews, vol. 23, no. 5, pp. 599–622, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Lenzen, “The mechanisms of alloxan- and streptozotocin-induced diabetes,” Diabetologia, vol. 51, no. 2, pp. 216–226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. D. Accili, “Lilly lecture 2003: The struggle for mastery in insulin action: From triumvirate to republic,” Diabetes, vol. 53, no. 7, pp. 1633–1642, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. W. Cao, Q. F. Collins, T. C. Becker et al., “p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis,” The Journal of Biological Chemistry, vol. 280, no. 52, pp. 42731–42737, 2005. View at Publisher · View at Google Scholar · View at Scopus