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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 6268378, 10 pages
Research Article

Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1

1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China
2Shandong Food and Drug Administration, Jinan, Shandong 250014, China
3College of Foreign Language, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China

Correspondence should be addressed to XuMing Ji

Received 25 July 2016; Revised 11 January 2017; Accepted 17 January 2017; Published 14 February 2017

Academic Editor: José L. Ríos

Copyright © 2017 YaNan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to investigate the mechanisms of Chinese herbal medicine called “Baoyuan Jiedu” (BYJD for short) decoction, improving life quality and preventing muscle atrophy of cancer cachexia model mice. We showed that the effect of BYJD decoction increased body weights of mice and reduced tumor volume and tumor mass. Furthermore, BYJD decoction increased the gastrocnemii mass and the transverse diameter of muscle fiber morphology. Moreover, BYJD reduced the expression of Atrogin-1 and MuRF-1 protein. Collectively, our results show that BYJD decoction improves the life quality of cancer cachexia mice and prevents muscle atrophy by downregulating expression of Atrogin-1 and MuRF-1.