The Use of Omic Technologies Applied to Traditional Chinese Medicine Research
Table 3
Studies on TCM using omic technologies (P, proteomics; T, transcriptomics; M, metabolomics; PG; pharmacogenomics; G, genomics; L, lipidomics).
Disease
TCM
Omic approach: method
Target or signaling pathway
Reference
Parkinson’s disease
Acanthopanax senticosus
P: iTRAQ
Inhibition of the expression of Lewy bodies; modulation of mitochondrial energy metabolism, axonal transport, and protein degradation; suppression of endoplasmic reticulum stress and apoptosis; maintenance of centrosome integrity, iron, and calcium homeostasis
Cardiac acute toxicity by inhibition of the Na+/K+ -ATPase pump, activation of the mitochondrial apoptotic pathway, increasing the levels of ROS, disturbance of mitochondrial function, and induction of apoptosis
Restoration to normal urinary levels of citric acid, creatine, pantothenic acid, carnitine, pantothenic acid, phenylacetylglycine and plasma levels of uric acid, L-histidine, and L-phenylalanine
PG: PCR array, microarray-based transcriptome-wide mRNA expressions, and COMPARE analysis
Induction of apoptosis by regulation of tumor suppressors p53, p21, mitochondrial Bax and Bcl-2 proteins, JAK/STAT pathway, NF-KB, and oxidative stress that leads to DNA damage
Downregulation of apoptosis, inflammation, angiogenesis, and blood coagulation genes; upregulation of neurogenesis and nervous system development genes
Reduction of lipopolysaccharide-induced damage, improvement of the physiological and biochemical responses to overcome the action of lipopolysaccharides
Stimulation of angiogenesis, modulation of PI3k and AKT pathways, regulation of cell adhesion, migration, and cytoskeleton. Effect on nuclear steroid hormone receptors