Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K⁺ Channel Activation Dependent

Table 3

Effect of BDME on serum parameters in vincristine induced neuropathic pain in rats.

	Dose; (mg/kg)	ALP; (U/l)	ALT; (U/l)	AST; (U/l)	Creatinine; (mg/dl)
Normal control	-	72.80 ± 1.83	41.20 ± 2.56	44.00 ± 2.03	0.41 ± 0.03
Vincristine + vehicle	-	481.00 ± 9.68	182.00 ± 7.23	136.00 ± 3.03	0.87 ± 0.01
Vincristine + Morphine	5	186.00 ± 27.70	85.00 ± 4.18	97.00 ± 3.03	0.58 ± 0.03
Vincristine + BDME	500	87.00 ± 2.68	48.40 ± 2.16	74.40 ± 2.23	0.41 ± 0.03

ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. Each value represents the mean ± ESM for six animals and analyzed by two-way ANOVA followed by Tukey post hoc test, when compared to normal control, when compared to vincristine and vehicle.