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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 6376173, 15 pages
https://doi.org/10.1155/2017/6376173
Research Article

Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia

1Northeast Biotechnology Network, Graduate Program of Biotechnology, State University of Ceará, Itaperi Campus, 60714-903 Fortaleza, CE, Brazil
2Laboratory of Biotechnology and Molecular Biology and Health Science Center, State University of Ceará, Itaperi Campus, 60714-903 Fortaleza, CE, Brazil
3Faculty of Veterinary, State University of Ceará, Itaperi Campus, 60714-903 Fortaleza, CE, Brazil
4Federal University of Piauí, Campus Senador Helvídio Nunes de Barros, Junco, 64607-670 Picos, PI, Brazil
5Laboratory of Veterinary Pathology, State University of Ceará, Itaperi Campus, 60740-000 Fortaleza, CE, Brazil
6Federal University of Ceará, University Campus of Pici, 60356-000 Fortaleza, CE, Brazil
7Laboratory of Natural Products, State University of Ceará, Itaperi Campus, 60740-000 Fortaleza, CE, Brazil

Correspondence should be addressed to Raquel Teixeira Terceiro Paim; rb.moc.oohay@miapleuqar

Received 12 January 2017; Revised 31 March 2017; Accepted 3 May 2017; Published 11 June 2017

Academic Editor: Menaka C. Thounaojam

Copyright © 2017 Raquel Teixeira Terceiro Paim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, 1H and 13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.