Standardized Kaempferia parviflora Extract Inhibits Intrinsic Aging Process in Human Dermal Fibroblasts and Hairless Mice by Inhibiting Cellular Senescence and Mitochondrial Dysfunction

Figure 8

Effect of KPE on cellular senescence in vivo. (a) SA-β-gal activity was detected using a fluorescence reader at 365 nm excitation and 460 nm emission. (b) mRNA expression of p53, p21, p16, and pRb was evaluated via RT-PCR (c) The protein expression of p53, p21, p16, and pRb was evaluated via western blotting. Data are expressed as mean ± SD of five mice in each group. ^##p < 0.01 compared to young mice; < 0.05 and < 0.01 compared to intrinsically MA mice.

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