Standardized Kaempferia parviflora Extract Inhibits Intrinsic Aging Process in Human Dermal Fibroblasts and Hairless Mice by Inhibiting Cellular Senescence and Mitochondrial Dysfunction

Figure 9

Effect of KPE on mitochondrial dysfunction in vivo. (a) Effect of KPE on mtDNA expression. (b) mRNA expression of PGC-1α, NRF-1, ERRα, and Tfam was evaluated via RT-PCR. (c) The protein expression of PGC-1α was evaluated via western blotting. Data are expressed as mean ± SD of five mice in each group. ^##p < 0.01 compared to young mice; < 0.01 compared to intrinsically MA mice.

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