Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers

Figure 3

Group (MORE, control) × time (Pre, Post) interaction in right rostral ACC (rACC)-OFC (, , ) resting-state functional connectivity, = 19.8, = 2.69, (, α = .05, Monte Carlo). The rACC seed was defined by a conjunction mask from the functional ROI clusters from the significant interaction revealed in the positive ER & CR model. Among smokers in the MORE condition, rsFC between rACC and OFC strengthened from baseline to 8 weeks post-MORE, whereas the control group evidenced weaker rsFC between these regions.