Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept

Table 1

Demographic, clinical, and tumoral characteristics of 310 patients.

Characteristics	Total	YC	YH
	(11 without EGFR status)	(7 without EGFR status)	(4 without EGFR status)
Gender				<0.00
Male (n, %)	202 (65.37%)	92 (52.57%)	110 (82.09%)
Female (n, %)	107 (34.63%)	83 (47.43%)	24 (17.91%)
Age (year, mean ± SD)	60.67 ± 10.86	59.78 ± 11.48	61.83 ± 9.90	0.02
Smoker				<0.00
Yes (n, %)	172 (55.66%)	70 (40.23%)	102 (75.56%)
No (n, %)	137 (44.34%)	104 (59.77%)	33 (24.44%)
Cancer history
Newly diagnosed (n, %)	269 (86.77%)	146 (83.43%)	123 (91.11%)
Recurrence (n, %)	41 (13.23%)	29 (16.57%)	12 (8.89%)
Primary location
Peripheral (n, %)	211 (73.26%)	124 (77.5%)	87 (67.97%)
Central (n, %)	77 (26.74%)	36 (22.5%)	41 (32.03%)
Stage
Non-IV (n, %)	69 (22.40%)	32 (18.39%)	37 (27.61%)
IV (n, %)	239 (77.60%)	142 (81.61%)	97 (72.39%)
Lung metastasis
Yes (n, %)	92 (30.16%)	58 (34.12%)	34 (25.19%)
No (n, %)	213 (69.84%)	112 (65.88%)	101 (74.81%)
Bone metastasis
Yes (n, %)	127 (43.20%)	79 (48.47%)	48 (36.64%)
No (n, %)	167 (56.80%)	84 (51.53%)	83 (63.36%)
Liver metastasis
Yes (n, %)	26 (8.64%)	16 (9.47%)	10 (7.58%)
No (n, %)	275 (91.36%)	153 (90.53%)	122 (92.42%)
Brain metastasis
Yes (n, %)	60 (20.27%)	36 (21.69%)	24 (18.46%)
No (n, %)	236 (79.73%)	130 (78.31%)	106 (81.54%)
Pathology
Nonsquamous (n, %)	262 (84.79%)	156 (89.66%)	106 (78.52%)
Squamous (n, %)	47 (15.21%)	18 (10.34%)	29 (21.48%)
PS
0~1	260 (85.53%)	151 (86.78%)	109 (83.85%)
2~4	44 (14.47%)	23 (13.22%)	21 (16.15%)
Height (cm, mean ± SD)	163.29 ± 7.57	161.14 ± 7.45	166.17 ± 6.76
Weight (kg, mean ± SD)	59.40 ± 10.69	58.00 ± 10.91	61.27 ± 10.14
Mean BP (mmHg, mean ± SD)	92.56 ± 10.16	91.15 ± 9.49	94.38 ± 10.72
EGFR status ※
Mutated (n, %)	110 (36.79%)	76 (45.24%)	34 (25.95%)
Wild (n, %)	189 (63.21%)	92 (54.76%)	97 (74.05%)
Exon 19 deletion
Yes (n, %)	51 (17.11%)	37 (22.02%)	14 (10.77%)
No (n, %)	247 (82.89%)	131 (77.98%)	116 (89.23%)
Exon 21 mutation
Yes (n, %)	46 (15.44%)	35 (20.83%)	11 (8.46%)
No (n, %)	252 (84.56%)	133 (79.17%)	119 (91.54%)
Rare mutation
Yes (n, %)	12 (4.03%)	4 (2.38%)	8 (6.15%)
No (n, %)	286 (95.97%)	164 (97.62%)	122 (93.85%)

Chi-square test.
t-test.
Spearman correlation coefficient: −0.198, (TCM syndrome types: Yin-cold = 0, Yang-heat = 1; EGFR status: wild = 0, mutated = 1).