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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 7217619, 8 pages
Research Article

Anxiolytic Effect of Citrus aurantium L. in Crack Users

1Postgraduate Program in Neuroscience Cognitive and Behavior, Federal University of Paraíba, João Pessoa, PB, Brazil
2Department of Nursing and Collective Health, Federal University of Paraíba, João Pessoa, PB, Brazil
3Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil
4Institute of Research in Drugs and Medicines, Federal University of Paraíba, João Pessoa, PB, Brazil

Correspondence should be addressed to Mateus Feitosa Alves; moc.liamg@sevlafsuetam

Received 5 April 2017; Accepted 7 September 2017; Published 18 October 2017

Academic Editor: Heba Abdelhalim

Copyright © 2017 Gabriel Chaves Neto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (HAS). EO was administered by nebulization. The experiment was developed in individual sessions and consolidated to four phases. The results demonstrated that the test subjects in the groups that were given the EO maintained controlled anxiety levels during SPS, when compared to the Control Group (no treatment). Subjects who used the EO also maintained levels of “discomfort” and “cognitive impairment” during SPS. It was concluded that individuals who are experiencing internal crack cocaine withdrawal present high anxiety traits and that nebulization of the EO of Citrus aurantium L. provided an acute anxiolytic effect in crack cocaine users exposed to SPS.