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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 7247016, 9 pages
https://doi.org/10.1155/2017/7247016
Research Article

Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

1Institut Charles Viollette (EA 7394), Université de Lille, 59000 Lille, France
2The Laboratory of Aromatic and Medicinal Plants, Biotechnology Centre of Borj-Cédria (CBBC), Hammam-lif, Tunisia
3Pharmacognosy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue E. Mounier, No. 72, B01.72.03-1200 Brussels, Belgium
4UDSL, INSERM U995, UFR Pharmacie, 59000 Lille, France

Correspondence should be addressed to Céline Rivière; rf.2ellil-vinu@3-ereivir.enilec

Received 22 March 2017; Accepted 6 June 2017; Published 12 July 2017

Academic Editor: Ken Yasukawa

Copyright © 2017 Ramla Sahli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Several Cirsium species are known for their uses in traditional medicine and consequently are studied for their phytochemical content and their biological activities. In the framework of a previous study conducted on eight extremophile plants from Tunisia, we highlighted that the crude methanolic extract of C. scabrum, a not investigated thistle, showed moderate but quite selective cytotoxic activity against the cancerous cell line J774 compared to the noncancerous cell line WI38 (IC50 = 11.53 μg/ml on J774, IC50 = 29.89 µg/ml on WI38, and selectivity index = 2.6). In the current study, the partitions of the leaves of C. scabrum were analyzed for their antiproliferative activity on the same cell lines. From the most active petroleum ether partition, we isolated four triterpenoids including lupeol, taraxasterol acetate, and a (1 : 1) mixture of 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol. These two cycloartane-type triterpenoids are mostly responsible for this cytotoxic activity. On the other hand, the antimicrobial potential of this plant was also evaluated against 36 microorganisms. The moderate antibacterial activity against 6 Staphylococcus aureus and 2 Dermabacter hominis strains is mainly attributed to the butanol partition whose major compounds are glycosides of flavones.