Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Table 1

In vitro cytotoxicity of the crude extract and partitions of C. scabrum leaves.

Crude extract and partitions	WI38; IC50 (µg/ml)	J774; IC50 (µg/ml)	SI; (/IC50 J774)
CSRW	29.89 ± 2.38	11.53 ± 1.07
CSPE	33.21 ± 2.22	12.12 ± 0.34
CSMC	>50	48.13 ± 1.87	>1
CSEA	>50	40.97 ± 2.91
CSBt	>50	>50	>1
CSW	>50	>50	>1
Camptothecin	0.175 ± 0.029	0.011 ± 0.002

CSRW: C. scabrum leaves crude extract; CSPE: C. scabrum leaves petroleum ether partition; CSMC: C. scabrum leaves methylene chloride partition; CSEA: C. scabrum leaves ethyl acetate partition; CSBt: C. scabrum leaves butanol partition; CSW: C. scabrum leaves water partition; camptothecin: positive control; results are expressed as mean ± standard error of the mean (SEM) from six determinations and activity differences between cell lines are statistically defined for each partition with the Mann–Whitney or Wilcoxon signed-rank tests for comparison to the highest tested concentration (, ).