Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Table 3

In vitro cytotoxicity of isolated compounds from the combined fractions CSPE4/CSPE5.

	WI38; IC50 (µg/ml)	J774; IC50 (µg/ml)	IS; (/IC50 J774)
Compound 1	19.24 ± 0.55 (4.51 µM)	12.60 ± 0.23; (2.96 µM)
Mixture of compounds 3a/3b	16.50 ± 0.24; (3.6 µM)	1.79 ± 0.03 (0.39 µM)
Camptothecin	0.175 ± 0.08; (0.05 µM)	0.011 ± 0.004; (0.0031 µM)

Compound 1: lupeol; mixture of compounds 3a/3b: 25-hydroperoxycycloart-23-en-3β-ol and 24-hydroperoxycycloart-25-en-3β-ol; camptothecin: positive control; results are expressed as mean ± standard error of the mean (SEM) of six determinations and activity differences between cell lines are statistically defined for each compound with the Mann–Whitney or Wilcoxon signed-rank tests for comparison to the highest tested concentration ().