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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 7298683, 12 pages
Research Article

The Antioxidative, Antiaging, and Hepatoprotective Effects of Alkali-Extractable Polysaccharides by Agaricus bisporus

1Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences, Key Laboratory of Wastes Matrix Utilization, Ministry of Agriculture, Jinan 250100, China
2College of Life Science, Shandong Agricultural University, Tai’an 271018, China
3Key Laboratory of Plant Nutrition and Fertilizer, Ministry of Agriculture/Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Correspondence should be addressed to Zhiyuan Gong; moc.621@6562yzgds and Le Jia; moc.361@5250elaij

Received 17 March 2017; Revised 22 June 2017; Accepted 6 July 2017; Published 22 August 2017

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2017 Shangshang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this work was designed to investigate the antioxidant, antiaging, and hepatoprotective effects of alkali-extractable polysaccharides (AlAPS) and their three purified fractions (AlAPS-1, AlAPS-2, and AlAPS-3) from Agaricus bisporus in D-galactose induced aging mice. For in vitro antioxidant analysis, both AlAPS and its fractions exhibited moderate reducing power, Fe2+-chelating activities, and potent scavenging activities on hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. The in vivo results demonstrated that the polysaccharides, especially AlAPS-2, showed potential antiaging and hepatoprotective effects by enhancing the antioxidant status, decreasing serum hepatic enzyme activities, and improving the lipid metabolism. This study suggested that the polysaccharides extracted and purified from A. bisporus could be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases.